Acute paternal alcohol exposure impairs fertility and fetal outcome

Theodore J. Cicero; Bruce Nock; Lynn H. O'Connor; Bryan N. Sewing; Michael L. Adams; E. Robert Meyer

doi:10.1016/0024-3205(94)90109-0

Acute paternal alcohol exposure impairs fertility and fetal outcome

Theodore J. Cicero, Bruce Nock, Lynn H. O'Connor, Bryan N. Sewing, Michael L. Adams, E. Robert Meyer

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (>50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sired by alcohol-treated males: litter sizes were appreciably smaller (30%) and fetal mortality was more than 2 times higher than in controls. These results suggest that paternal alcohol use, like maternal alcohol abuse, may adversely affect fertility and fetal outcome.

Original language	English
Pages (from-to)	PL33-PL36
Journal	Life Sciences
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/0024-3205(94)90109-0
State	Published - 1994

Keywords

alcohol
fertility
fetal anomalies
paternal alcohol exposure

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10.1016/0024-3205(94)90109-0

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abstract = "An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (>50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sired by alcohol-treated males: litter sizes were appreciably smaller (30%) and fetal mortality was more than 2 times higher than in controls. These results suggest that paternal alcohol use, like maternal alcohol abuse, may adversely affect fertility and fetal outcome.",

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AU - Nock, Bruce

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AU - Sewing, Bryan N.

AU - Adams, Michael L.

AU - Robert Meyer, E.

PY - 1994

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N2 - An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (>50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sired by alcohol-treated males: litter sizes were appreciably smaller (30%) and fetal mortality was more than 2 times higher than in controls. These results suggest that paternal alcohol use, like maternal alcohol abuse, may adversely affect fertility and fetal outcome.

AB - An acute injection of an intoxicating dose of alcohol to male rats 24 hours prior to breeding with drug-naive females produced no discernible effect on copulatory activity, as reflected in vaginal plugs, but resulted in markedly (>50%) reduced pregnancy rates. Fetal outcome was also markedly affected in offspring sired by alcohol-treated males: litter sizes were appreciably smaller (30%) and fetal mortality was more than 2 times higher than in controls. These results suggest that paternal alcohol use, like maternal alcohol abuse, may adversely affect fertility and fetal outcome.

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KW - fertility

KW - fetal anomalies

KW - paternal alcohol exposure

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Acute paternal alcohol exposure impairs fertility and fetal outcome

Abstract

Keywords

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