Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: Is there a link?

Leena Kandula, Seema Khan, David C. Whitcomb, Mark E. Lowe

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Context: Acute pancreatitis has occasionally been reported in association with Campylobacter jejuni infection in humans. However, the mechanism linking Campylobacter jejuni infection and pancreatitis is unclear. Acute pancreatitis in association with an infectious illness may be related to underlying genetic mutations. For instance, studies show that mutations in the cystic fibrosis transmembrane conductance regulator gene increase the susceptibility for acute and chronic pancreatitis. Case report: We describe a patient with Campylobacter jejuni infection who developed acute pancreatitis in the setting of an underlying cystic fibrosis transmembrane conductance regulator gene mutation. Discussion: In this patient with an underlying mutation in the CFTR gene, we propose that the interaction between the mutant gene and an environmental factor, Campylobacter jejuni infection, resulted in pancreatitis.

Original languageEnglish
Pages (from-to)482-485
Number of pages4
JournalJournal of the Pancreas
Volume7
Issue number5
StatePublished - Sep 2006

Keywords

  • Acute Necrotizing
  • Campylobacter jejuni
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Pancreatitis
  • Pediatrics

Fingerprint

Dive into the research topics of 'Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: Is there a link?'. Together they form a unique fingerprint.

Cite this