Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Francisco D.Rocha Filho; Gabrielle G. Lima; Francisco V. Ferreira; Nadjane B.A. Miranda; Franklin J.C. Santos; Andrea A. Vieira; Nidia C. Messias

Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Francisco D.Rocha Filho, Gabrielle G. Lima, Francisco V. Ferreira, Nadjane B.A. Miranda, Franklin J.C. Santos, Andrea A. Vieira, Nidia C. Messias

Division of Anatomic and Molecular Pathology (AMP)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been mported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21) (q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.

Original language	English
Pages (from-to)	423-425
Number of pages	3
Journal	Revista Brasileira de Hematologia e Hemoterapia
Volume	30
Issue number	5
State	Published - Sep 2008

Keywords

Acute myeloid leukemia
Breast
Granulocytic sarcoma

Cite this

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title = "Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma",

abstract = "Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been mported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21) (q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.",

keywords = "Acute myeloid leukemia, Breast, Granulocytic sarcoma",

author = "Filho, {Francisco D.Rocha} and Lima, {Gabrielle G.} and Ferreira, {Francisco V.} and Miranda, {Nadjane B.A.} and Santos, {Franklin J.C.} and Vieira, {Andrea A.} and Messias, {Nidia C.}",

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T1 - Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

AU - Filho, Francisco D.Rocha

AU - Lima, Gabrielle G.

AU - Ferreira, Francisco V.

AU - Miranda, Nadjane B.A.

AU - Santos, Franklin J.C.

AU - Vieira, Andrea A.

AU - Messias, Nidia C.

PY - 2008/9

Y1 - 2008/9

N2 - Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been mported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21) (q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.

AB - Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been mported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21) (q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.

KW - Acute myeloid leukemia

KW - Breast

KW - Granulocytic sarcoma

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SN - 1516-8484

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Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Abstract

Keywords

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