TY - JOUR
T1 - Acute Myeloid Leukemia
T2 - The Good, the Bad, and the Ugly
AU - Kuykendall, Andrew
AU - Duployez, Nicolas
AU - Boissel, Nicolas
AU - Lancet, Jeffrey E.
AU - Welch, John S.
PY - 2018/5/23
Y1 - 2018/5/23
N2 - Acute myeloid leukemia (AML) was initially subdivided according to morphology (the French-American-British system), which proved helpful in pathologic categorization. Subsequently, clinical and genomic factors were found to correlate with response to chemotherapy and with overall survival. These included a history of antecedent hematologic disease, a history of chemotherapy or radiation therapy, the presence of various recurrent cytogenetic abnormalities, and, more recently, the presence of specific point mutations. This article reviews the biology and responses of one AML subgroup with consistent response and good outcomes following chemotherapy (core-binding factor leukemia), and two subgroups with persistently bad, and even ugly, outcomes (secondary AML and TP53-mutated AML).
AB - Acute myeloid leukemia (AML) was initially subdivided according to morphology (the French-American-British system), which proved helpful in pathologic categorization. Subsequently, clinical and genomic factors were found to correlate with response to chemotherapy and with overall survival. These included a history of antecedent hematologic disease, a history of chemotherapy or radiation therapy, the presence of various recurrent cytogenetic abnormalities, and, more recently, the presence of specific point mutations. This article reviews the biology and responses of one AML subgroup with consistent response and good outcomes following chemotherapy (core-binding factor leukemia), and two subgroups with persistently bad, and even ugly, outcomes (secondary AML and TP53-mutated AML).
UR - http://www.scopus.com/inward/record.url?scp=85057240268&partnerID=8YFLogxK
U2 - 10.1200/EDBK_199519
DO - 10.1200/EDBK_199519
M3 - Review article
C2 - 30231330
AN - SCOPUS:85057240268
SN - 1548-8756
SP - 555
EP - 573
JO - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
JF - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
IS - 38
ER -