Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines

Patrick A. Brown; Matthew Wieduwilt; Aaron Logan; Daniel J. DeAngelo; Eunice S. Wang; Amir Fathi; Ryan D. Cassaday; Mark Litzow; Anjali Advani; Patricia Aoun; Bhavana Bhatnagar; Michael W. Boyer; Teresa Bryan; Patrick W. Burke; Peter F. Coccia; Steven E. Coutre; Nitin Jain; Suzanne Kirby; Arthur Liu; Stephanie Massaro; Ryan J. Mattison; Olalekan Oluwole; Nikolaos Papadantonakis; Jae Park; Jeffrey E. Rubnitz; Geoffrey L. Uy; Kristina M. Gregory; Ndiya Ogba; Bijal Shah

doi:10.6004/jnccn.2019.0024

Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines

Patrick A. Brown
, Matthew Wieduwilt
, Aaron Logan
, Daniel J. DeAngelo
, Eunice S. Wang
, Amir Fathi
, Ryan D. Cassaday
, Mark Litzow
, Anjali Advani
, Patricia Aoun
, Bhavana Bhatnagar
, Michael W. Boyer
, Teresa Bryan
, Patrick W. Burke
, Peter F. Coccia
, Steven E. Coutre
, Nitin Jain
, Suzanne Kirby
, Arthur Liu
, Stephanie Massaro

Ryan J. Mattison, Olalekan Oluwole, Nikolaos Papadantonakis, Jae Park, Jeffrey E. Rubnitz, Geoffrey L. Uy, Kristina M. Gregory, Ndiya Ogba, Bijal Shah

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Survival outcomes for older adults with acute lymphoblastic leukemia (ALL) are poor and optimal management is challenging due to higher-risk leukemia genetics, comorbidities, and lower tolerance to intensive therapy. A critical understanding of these factors guides the selection of frontline therapies and subsequent treatment strategies. In addition, there have been recent developments in minimal/measurable residual disease (MRD) testing and blinatumomab use in the context of MRD-positive disease after therapy. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines for ALL regarding upfront therapy in older adults and MRD monitoring/testing in response to ALL treatment.

Original language	English
Pages (from-to)	414-423
Number of pages	10
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	17
Issue number	5
DOIs	https://doi.org/10.6004/jnccn.2019.0024
State	Published - 2019

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Brown, P. A., Wieduwilt, M., Logan, A., DeAngelo, D. J., Wang, E. S., Fathi, A., Cassaday, R. D., Litzow, M., Advani, A., Aoun, P., Bhatnagar, B., Boyer, M. W., Bryan, T., Burke, P. W., Coccia, P. F., Coutre, S. E., Jain, N., Kirby, S., Liu, A., ... Shah, B. (2019). Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines. JNCCN Journal of the National Comprehensive Cancer Network, 17(5), 414-423. https://doi.org/10.6004/jnccn.2019.0024

@article{ea6e3d3cdc784de6bce1c46b4bd7fb09,

title = "Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines",

abstract = "Survival outcomes for older adults with acute lymphoblastic leukemia (ALL) are poor and optimal management is challenging due to higher-risk leukemia genetics, comorbidities, and lower tolerance to intensive therapy. A critical understanding of these factors guides the selection of frontline therapies and subsequent treatment strategies. In addition, there have been recent developments in minimal/measurable residual disease (MRD) testing and blinatumomab use in the context of MRD-positive disease after therapy. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines for ALL regarding upfront therapy in older adults and MRD monitoring/testing in response to ALL treatment.",

author = "Brown, \{Patrick A.\} and Matthew Wieduwilt and Aaron Logan and DeAngelo, \{Daniel J.\} and Wang, \{Eunice S.\} and Amir Fathi and Cassaday, \{Ryan D.\} and Mark Litzow and Anjali Advani and Patricia Aoun and Bhavana Bhatnagar and Boyer, \{Michael W.\} and Teresa Bryan and Burke, \{Patrick W.\} and Coccia, \{Peter F.\} and Coutre, \{Steven E.\} and Nitin Jain and Suzanne Kirby and Arthur Liu and Stephanie Massaro and Mattison, \{Ryan J.\} and Olalekan Oluwole and Nikolaos Papadantonakis and Jae Park and Rubnitz, \{Jeffrey E.\} and Uy, \{Geoffrey L.\} and Gregory, \{Kristina M.\} and Ndiya Ogba and Bijal Shah",

note = "Publisher Copyright: {\textcopyright} National Comprehensive Cancer Network, Inc. 2019.",

year = "2019",

doi = "10.6004/jnccn.2019.0024",

language = "English",

volume = "17",

pages = "414--423",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

issn = "1540-1405",

number = "5",

}

Brown, PA, Wieduwilt, M, Logan, A, DeAngelo, DJ, Wang, ES, Fathi, A, Cassaday, RD, Litzow, M, Advani, A, Aoun, P, Bhatnagar, B, Boyer, MW, Bryan, T, Burke, PW, Coccia, PF, Coutre, SE, Jain, N, Kirby, S, Liu, A, Massaro, S, Mattison, RJ, Oluwole, O, Papadantonakis, N, Park, J, Rubnitz, JE, Uy, GL, Gregory, KM, Ogba, N & Shah, B 2019, 'Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines', JNCCN Journal of the National Comprehensive Cancer Network, vol. 17, no. 5, pp. 414-423. https://doi.org/10.6004/jnccn.2019.0024

TY - JOUR

T1 - Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines

AU - Brown, Patrick A.

AU - Wieduwilt, Matthew

AU - Logan, Aaron

AU - DeAngelo, Daniel J.

AU - Wang, Eunice S.

AU - Fathi, Amir

AU - Cassaday, Ryan D.

AU - Litzow, Mark

AU - Advani, Anjali

AU - Aoun, Patricia

AU - Bhatnagar, Bhavana

AU - Boyer, Michael W.

AU - Bryan, Teresa

AU - Burke, Patrick W.

AU - Coccia, Peter F.

AU - Coutre, Steven E.

AU - Jain, Nitin

AU - Kirby, Suzanne

AU - Liu, Arthur

AU - Massaro, Stephanie

AU - Mattison, Ryan J.

AU - Oluwole, Olalekan

AU - Papadantonakis, Nikolaos

AU - Park, Jae

AU - Rubnitz, Jeffrey E.

AU - Uy, Geoffrey L.

AU - Gregory, Kristina M.

AU - Ogba, Ndiya

AU - Shah, Bijal

PY - 2019

Y1 - 2019

N2 - Survival outcomes for older adults with acute lymphoblastic leukemia (ALL) are poor and optimal management is challenging due to higher-risk leukemia genetics, comorbidities, and lower tolerance to intensive therapy. A critical understanding of these factors guides the selection of frontline therapies and subsequent treatment strategies. In addition, there have been recent developments in minimal/measurable residual disease (MRD) testing and blinatumomab use in the context of MRD-positive disease after therapy. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines for ALL regarding upfront therapy in older adults and MRD monitoring/testing in response to ALL treatment.

AB - Survival outcomes for older adults with acute lymphoblastic leukemia (ALL) are poor and optimal management is challenging due to higher-risk leukemia genetics, comorbidities, and lower tolerance to intensive therapy. A critical understanding of these factors guides the selection of frontline therapies and subsequent treatment strategies. In addition, there have been recent developments in minimal/measurable residual disease (MRD) testing and blinatumomab use in the context of MRD-positive disease after therapy. These NCCN Guidelines Insights discuss recent updates to the NCCN Guidelines for ALL regarding upfront therapy in older adults and MRD monitoring/testing in response to ALL treatment.

UR - https://www.scopus.com/pages/publications/85066289260

U2 - 10.6004/jnccn.2019.0024

DO - 10.6004/jnccn.2019.0024

M3 - Article

C2 - 31085755

AN - SCOPUS:85066289260

SN - 1540-1405

VL - 17

SP - 414

EP - 423

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 5

ER -

Acute lymphoblastic leukemia, version 1.2019 featured updates to the NCCN guidelines

Abstract

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