Acute leukemia of ambiguous lineage with trisomy 4 as the sole cytogenetic abnormality: A case report and literature review

S. Moraveji, A. Torabi, Z. Nahleh, S. Farrag, S. Gaur

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic blasts. Prognosis seems to be poor. Treatment with acute lymphoblastic leukemia like regimens seems to be superior compared to acute myeloid leukemia like regimens and allogeneic stem cell transplant is recommended after achieving remission.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalLeukemia Research Reports
Volume3
Issue number2
DOIs
StatePublished - May 2 2014

Keywords

  • Acute leukemia ambiguous lineage
  • Biphenotypic leukemia
  • C-Kit
  • Trisomy 4

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