TY - JOUR
T1 - Acute leukemia of ambiguous lineage with trisomy 4 as the sole cytogenetic abnormality
T2 - A case report and literature review
AU - Moraveji, S.
AU - Torabi, A.
AU - Nahleh, Z.
AU - Farrag, S.
AU - Gaur, S.
N1 - Publisher Copyright:
© 2014 The Authors.
PY - 2014/5/2
Y1 - 2014/5/2
N2 - We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic blasts. Prognosis seems to be poor. Treatment with acute lymphoblastic leukemia like regimens seems to be superior compared to acute myeloid leukemia like regimens and allogeneic stem cell transplant is recommended after achieving remission.
AB - We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic blasts. Prognosis seems to be poor. Treatment with acute lymphoblastic leukemia like regimens seems to be superior compared to acute myeloid leukemia like regimens and allogeneic stem cell transplant is recommended after achieving remission.
KW - Acute leukemia ambiguous lineage
KW - Biphenotypic leukemia
KW - C-Kit
KW - Trisomy 4
UR - http://www.scopus.com/inward/record.url?scp=84923252988&partnerID=8YFLogxK
U2 - 10.1016/j.lrr.2014.04.003
DO - 10.1016/j.lrr.2014.04.003
M3 - Article
AN - SCOPUS:84923252988
SN - 2213-0489
VL - 3
SP - 33
EP - 35
JO - Leukemia Research Reports
JF - Leukemia Research Reports
IS - 2
ER -