Acute kidney injury pathology and pathophysiology: A retrospective review

Joseph P. Gaut; Helen Liapis

doi:10.1093/ckj/sfaa142

Acute kidney injury pathology and pathophysiology: A retrospective review

Joseph P. Gaut, Helen Liapis

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.

Original language	English
Pages (from-to)	526-536
Number of pages	11
Journal	Clinical Kidney Journal
Volume	14
Issue number	2
DOIs	https://doi.org/10.1093/ckj/sfaa142
State	Published - Feb 1 2021

Keywords

AKI
acute tubular necrosis
hemoglobinuria
multiple myeloma
pathology
pathophysiology
review
rhabdomyolysis

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10.1093/ckj/sfaa142

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title = "Acute kidney injury pathology and pathophysiology: A retrospective review",

abstract = "Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.",

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AU - Liapis, Helen

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N2 - Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.

AB - Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.

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KW - hemoglobinuria

KW - multiple myeloma

KW - pathology

KW - pathophysiology

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KW - rhabdomyolysis

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Acute kidney injury pathology and pathophysiology: A retrospective review

Abstract

Keywords

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