Acute kidney injury pathology and pathophysiology: A retrospective review

Joseph P. Gaut, Helen Liapis

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Acute kidney injury (AKI) is the clinical term used for decline or loss of renal function. It is associated with chronic kidney disease (CKD) and high morbidity and mortality. However, not all causes of AKI lead to severe consequences and some are reversible. The underlying pathology can be a guide for treatment and assessment of prognosis. The Kidney Disease: Improving Global Outcomes guidelines recommend that the cause of AKI should be identified if possible. Renal biopsy can distinguish specific AKI entities and assist in patient management. This review aims to show the pathology of AKI, including glomerular and tubular diseases.

Original languageEnglish
Pages (from-to)526-536
Number of pages11
JournalClinical Kidney Journal
Issue number2
StatePublished - Feb 1 2021


  • AKI
  • acute tubular necrosis
  • hemoglobinuria
  • multiple myeloma
  • pathology
  • pathophysiology
  • review
  • rhabdomyolysis


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