TY - JOUR
T1 - Acute kidney injury in hematopoietic stem cell transplantation
AU - Wanchoo, Rimda
AU - Stotter, Brian R.
AU - Bayer, Ruthee L.
AU - Jhaveri, Kenar D.
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Purpose of review Acute kidney injury (AKI) in the setting of hematopoietic stem cell transplantation (HSCT) is common in pediatric and adult patients. The incidence ranges from 12 to 66%, and development of AKI in the posttransplant course is independently associated with higher mortality.Recent findingsPatients who undergo HSCT have many risk factors for developing AKI, including sepsis, use of nephrotoxic medications, graft versus host disease (GVHD), and veno-occlusive disease (VOD). In addition, engraftment syndrome/cytokine storm, transplant-associated thrombotic microangiopathy (TA-TMA), and less common infections with specific renal manifestations, such as BK and adenovirus nephritis, may lead to kidney injury. There has been significant advancement in the understanding of TA-TMA in particular, especially the role of the complement system in its pathophysiology. The role of early dialysis has been explored in the pediatric population, but not well studied in adult HSCT recipientsSummaryThis review provides an update on the risk factors, causes, and treatment approaches to HSCT-associated AKI.Video abstracthttp://links.lww.com/COCC/A29.
AB - Purpose of review Acute kidney injury (AKI) in the setting of hematopoietic stem cell transplantation (HSCT) is common in pediatric and adult patients. The incidence ranges from 12 to 66%, and development of AKI in the posttransplant course is independently associated with higher mortality.Recent findingsPatients who undergo HSCT have many risk factors for developing AKI, including sepsis, use of nephrotoxic medications, graft versus host disease (GVHD), and veno-occlusive disease (VOD). In addition, engraftment syndrome/cytokine storm, transplant-associated thrombotic microangiopathy (TA-TMA), and less common infections with specific renal manifestations, such as BK and adenovirus nephritis, may lead to kidney injury. There has been significant advancement in the understanding of TA-TMA in particular, especially the role of the complement system in its pathophysiology. The role of early dialysis has been explored in the pediatric population, but not well studied in adult HSCT recipientsSummaryThis review provides an update on the risk factors, causes, and treatment approaches to HSCT-associated AKI.Video abstracthttp://links.lww.com/COCC/A29.
KW - acute kidney injury
KW - bone marrow transplant
KW - hematopoietic stem cell transplantation
KW - onconephrology
KW - thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=85072173705&partnerID=8YFLogxK
U2 - 10.1097/MCC.0000000000000657
DO - 10.1097/MCC.0000000000000657
M3 - Review article
C2 - 31524721
AN - SCOPUS:85072173705
SN - 1070-5295
VL - 25
SP - 531
EP - 538
JO - Current Opinion in Critical Care
JF - Current Opinion in Critical Care
IS - 6
ER -