Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns

Anna D. Baker, Lee H. Schwamm, Danita Y. Sanborn, Karen Furie, Christoph Stretz, Brian Mac Grory, Shadi Yaghi, Dawn Kleindorfer, Heidi Sucharew, Jason Mackey, Kyle Walsh, Matt Flaherty, Brett Kissela, Kathleen Alwell, Jane Khoury, Pooja Khatri, Opeolu Adeoye, Simona Ferioli, Daniel Woo, Sharyl MartiniFelipe De Los Rios La Rosa, Stacie L. Demel, Tracy Madsen, Michael Star, Elisheva Coleman, Sabreena Slavin, Adam Jasne, Eva A. Mistry, Mary Haverbusch, Alexander E. Merkler, Hooman Kamel, Joseph Schindler, Lauren H. Sansing, Kamil F. Faridi, Lissa Sugeng, Kevin N. Sheth, Richa Sharma

Research output: Contribution to journalArticlepeer-review


BACKGROUND: There are limited data about the epidemiology and secondary stroke prevention strategies used for patients with depressed left ventricular ejection fraction (LVEF) and sinus rhythm following an acute ischemic stroke (AIS). We sought to describe the prevalence of LVEF ≤40% and sinus rhythm among patients with AIS and antithrombotic treatment practice in a multi-center cohort from 2002 to 2018. METHODS: This was a multi-center, retrospective cohort study comprised of patients with AIS hospitalized in the Greater Cincinnati Northern Kentucky Stroke Study and 4 academic, hospital-based cohorts in the United States. A 1-stage meta-analysis of proportions was undertaken to calculate a pooled prevalence. Univariate analyses and an adjusted multivariable logistic regression model were performed to identify demographic, clinical, and echocardiographic characteristics associated with being prescribed an anticoagulant upon AIS hospitalization discharge. RESULTS: Among 14 338 patients with AIS with documented LVEF during the stroke hospitalization, the weighted pooled prevalence of LVEF ≤40% and sinus rhythm was 5.0% (95% CI, 4.1-6.0%; I2, 84.4%). Of 524 patients with no cardiac thrombus and no prior indication for anticoagulant who survived postdischarge, 200 (38%) were discharged on anticoagulant, 289 (55%) were discharged on antiplatelet therapy only, and 35 (7%) on neither. There was heterogeneity by site in the proportion discharged with an anticoagulant (22% to 45%, P<0.0001). Cohort site and National Institutes of Health Stroke Severity scale >8 (odds ratio, 2.0 [95% CI, 1.1-3.8]) were significant, independent predictors of being discharged with an anticoagulant in an adjusted analysis. CONCLUSIONS: Nearly 5% of patients with AIS have a depressed LVEF and are in sinus rhythm. There is significant variation in the clinical practice of antithrombotic therapy prescription by site and stroke severity. Given this clinical equipoise, further study is needed to define optimal antithrombotic treatment regimens for secondary stroke prevention in this patient population.

Original languageEnglish
Pages (from-to)1883-1891
Number of pages9
Issue number6
StatePublished - Jun 1 2022


  • atrial fibrillation
  • echocardiograph
  • ischemic stroke
  • prevalence


Dive into the research topics of 'Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns'. Together they form a unique fingerprint.

Cite this