Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection

Eric I. Elliott; Daisy Smith; Jonathan Lipscomb; Bubu Banini; Lindsay Meurer; Thomas H. Vanderford; Jeffrey A. Johnson; Dhanpat Jain; Amit Achhra

doi:10.1093/ofid/ofae170

Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection

Eric I. Elliott, Daisy Smith, Jonathan Lipscomb, Bubu Banini, Lindsay Meurer, Thomas H. Vanderford, Jeffrey A. Johnson, Dhanpat Jain, Amit Achhra

Division of Gastroenterology

Research output: Contribution to journal › Article › peer-review

Abstract

The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.

Original language	English
Article number	ofae170
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofae170
State	Published - Apr 1 2024

Keywords

acute HIV infection
acute hepatitis
acute retroviral syndrome
histopathology
human immunodeficiency virus
immunofluorescence
immunohistochemistry
liver
primary HIV infection
proviral DNA

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10.1093/ofid/ofae170

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title = "Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection",

abstract = "The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.",

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AU - Smith, Daisy

AU - Lipscomb, Jonathan

AU - Banini, Bubu

AU - Meurer, Lindsay

AU - Vanderford, Thomas H.

AU - Johnson, Jeffrey A.

AU - Jain, Dhanpat

AU - Achhra, Amit

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AB - The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.

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KW - acute hepatitis

KW - acute retroviral syndrome

KW - histopathology

KW - human immunodeficiency virus

KW - immunofluorescence

KW - immunohistochemistry

KW - liver

KW - primary HIV infection

KW - proviral DNA

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Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection

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