Acute allograft rejection after lung transplantation: Diagnosis and therapy

Murali M. Chakinala, Elbert P. Trulock

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Acute rejection remains a significant problem after lung transplantation. While it generally is a treatable condition, significant resources and therapies are directed toward its prevention and resolution. Its larger significance undoubtedly rests in its contribution to the pathogenesis of BOS. Significant questions regarding the origins of AR, the role of LBB, alternative histologic appearances of acute allograft injury, and optimal therapy remain. Controversy regarding the utility of surveillance bronchoscopy and preemptive treatment of occult AR persists because of lack of conclusive evidence. Future investigations might resolve these matters and provide more efficacious and less toxic therapies that will hopefully reduce the impact of chronic rejection and improve long-term outcomes.

Original languageEnglish
Pages (from-to)525-542
Number of pages18
JournalChest Surgery Clinics of North America
Volume13
Issue number3
DOIs
StatePublished - Aug 2003

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