Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing

Benjamin R. Arenkiel, Hiroshi Hasegawa, Jason J. Yi, Rylan S. Larsen, Michael L. Wallace, Benjamin D. Philpot, Fan Wang, Michael D. Ehlers

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The continued addition of new neurons to mature olfactory circuits represents a remarkable mode of cellular and structural brain plasticity. However, the anatomical configuration of newly established circuits, the types and numbers of neurons that form new synaptic connections, and the effect of sensory experience on synaptic connectivity in the olfactory bulb remain poorly understood. Using in vivo electroporation and monosynaptic tracing, we show that postnatal-born granule cells form synaptic connections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb. In addition, newly born granule cells receive extensive input from local inhibitory short axon cells, a poorly understood cell population. The connectivity of short axon cells shows clustered organization, and their synaptic input onto newborn granule cells dramatically and selectively expands with odor stimulation. Our findings suggest that sensory experience promotes the synaptic integration of new neurons into cell type-specific olfactory circuits.

Original languageEnglish
Article numbere29423
JournalPloS one
Volume6
Issue number12
DOIs
StatePublished - Dec 28 2011

Fingerprint Dive into the research topics of 'Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing'. Together they form a unique fingerprint.

  • Cite this

    Arenkiel, B. R., Hasegawa, H., Yi, J. J., Larsen, R. S., Wallace, M. L., Philpot, B. D., Wang, F., & Ehlers, M. D. (2011). Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. PloS one, 6(12), [e29423]. https://doi.org/10.1371/journal.pone.0029423