@article{a04981e194894d8f82a9211d08f16f17,
title = "Activity-dependent neuroplasticity induced by an enriched environment reverses cognitive deficits in scribble deficient mouse",
abstract = "Planar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched environment (EE) preserved memory formation in CaMK-Scrib-/- mice by recovering synaptic plasticity and maturation. Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive functions during adulthood.",
keywords = "Consolidation memory, LTD, Phosphatases, Planar cell polarity, Synapse",
author = "Hilal, {Muna L.} and Moreau, {Mait{\'e} M.} and Claudia Racca and Pinheiro, {Vera L.} and Piguel, {Nicolas H.} and Santoni, {Marie Jos{\'e}e} and {Santos Carvalho}, {Steve Dos} and Blanc, {Jean Michel} and Abada, {Yah Se K.} and Ronan Peyroutou and Chantal Medina and H{\'e}l{\`e}ne Doat and Thomas Papouin and Laurent Vuillard and Borg, {Jean Paul} and Rivka Rachel and Aude Panatier and Mireille Montcouquiol and Oliet, {St{\'e}phane H.R.} and Nathalie Sans",
note = "Funding Information: This work was supported by INSERM and INSERM AVENIR grants (NS and MM), Conseil R{\'e}gional d{\textquoteright}Aquitaine (NS/MM), Neurocampus program (MM), La Fondation pour la Recherche M{\'e}dicale (NS, MM), ANR NeuroScrib ANR-07-NEUR-031-01 (NS, MM), ANR MossyPCP ANR-12-BSV4-0016-01 (NS), Royal Society International Joint Project grant (CR, NS) and the Wellcome Trust Institutional Strategic Support Fund Project, Faculty of Medical Sciences, Newcastle University (CR). J.P. Borg{\textquoteright}s lab is funded by la Ligue Contre le Cancer (Label Ligue), INSERM, and Institut Paoli-Calmettes. MLH was an AXA funded student of the University of Bordeaux graduate programme and also Funding Information: received funding for a 4th year from the Fondation pour la Recherche Medicale (FRM; FDT20120925405). VLP was supported by a Ph.D. fellowship from the 7th Framework Program (FP7) Marie Curie ITN SyMBaD, the FRM “4eme ann{\'e}e de these” (FDT20130928124) and the Schizo Oui Foundation. SDSC is supported by an ENC Neurasmus Ph.D. fellowship. NHP was supported by the Conseil R{\'e}gional d{\textquoteright}Aquitaine/INSERM during his Ph.D. and the FRM “Bourse de soudure” fellowship. JP Borg is a scholar of Institut Universitaire de France. SHRO is supported by INSERM, Universit{\'e} de Bordeaux, and FRM (Equipe FRM; DEQ 201 303 26519). The Montcouquiol/Sans & Oliet labs are members of the Labex B.R.A.I.N. Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press.",
year = "2017",
month = dec,
day = "1",
doi = "10.1093/cercor/bhw333",
language = "English",
volume = "27",
pages = "5635--5651",
journal = "Cerebral Cortex",
issn = "1047-3211",
number = "12",
}