Activity, creatine kinase, and myoglobin in duchenne muscular dystrophy: A clue to etiology?

Julaine M. Florence; Peter T. Fox; G. James Planer; Michael H. Brooke

doi:10.1212/wnl.35.5.758

Activity, creatine kinase, and myoglobin in duchenne muscular dystrophy: A clue to etiology?

Julaine M. Florence, Peter T. Fox, G. James Planer, Michael H. Brooke

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51 Scopus citations

Abstract

Large and seemingly random fluctuations in the serum levels of creatine kinase (CK) and myoglobin (Mb) have been noted in patients with Duchenne muscular dystrophy. We studied seven affected boys, aged 2 to 9 years. Blood was drawn for CK and Mb every 4 hours, and the boys’ activity was documented hourly for 4 days. There was a close correlation between serum levels of CK and Mb with physical activity. Fluctuations in serum levels of CK and Mb are not random and may result from an abnormality of fatty acid metabolism.

Original language	English
Pages (from-to)	758-761
Number of pages	4
Journal	Neurology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1212/wnl.35.5.758
State	Published - May 1985

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title = "Activity, creatine kinase, and myoglobin in duchenne muscular dystrophy: A clue to etiology?",

abstract = "Large and seemingly random fluctuations in the serum levels of creatine kinase (CK) and myoglobin (Mb) have been noted in patients with Duchenne muscular dystrophy. We studied seven affected boys, aged 2 to 9 years. Blood was drawn for CK and Mb every 4 hours, and the boys{\textquoteright} activity was documented hourly for 4 days. There was a close correlation between serum levels of CK and Mb with physical activity. Fluctuations in serum levels of CK and Mb are not random and may result from an abnormality of fatty acid metabolism.",

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AB - Large and seemingly random fluctuations in the serum levels of creatine kinase (CK) and myoglobin (Mb) have been noted in patients with Duchenne muscular dystrophy. We studied seven affected boys, aged 2 to 9 years. Blood was drawn for CK and Mb every 4 hours, and the boys’ activity was documented hourly for 4 days. There was a close correlation between serum levels of CK and Mb with physical activity. Fluctuations in serum levels of CK and Mb are not random and may result from an abnormality of fatty acid metabolism.

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Activity, creatine kinase, and myoglobin in duchenne muscular dystrophy: A clue to etiology?

Abstract

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