Abstract

The stretch response of myofibroblast cells cultured in a three-dimensional environment was simultaneously measured and observed using a tissue stretching apparatus mounted to a confocal microscope. Optical measurements were used to assess mechanical estimates of cell response obtained through combined mechanical testing and biochemical inhibition. Results show that activated myofibroblasts provide an effective resistance on the order of 100s of kPa. In specific mechanical environments, stretched myofibroblasts release the ECM.

Original languageEnglish
Title of host publicationProceedings of the ASME Summer Bioengineering Conference, SBC2008
Pages649-650
Number of pages2
EditionPART B
StatePublished - 2009
Event10th ASME Summer Bioengineering Conference, SBC2008 - Marco Island, FL, United States
Duration: Jun 25 2008Jun 29 2008

Publication series

NameProceedings of the ASME Summer Bioengineering Conference, SBC2008
NumberPART B

Conference

Conference10th ASME Summer Bioengineering Conference, SBC2008
Country/TerritoryUnited States
CityMarco Island, FL
Period06/25/0806/29/08

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