TY - JOUR
T1 - Activation lateralization in human core, belt, and parabelt auditory fields with unilateral deafness compared to normal hearing
AU - Burton, Harold
AU - Firszt, Jill B.
AU - Holden, Timothy
AU - Agato, Alvin
AU - Uchanski, Rosalie M.
N1 - Funding Information:
A grant from the National Institutes of Deafness and Other Communication Disorders ( R01 DC009010 ) supported this research. The National Institute of Neurological Disorders and Stroke provided additional support for HB and AA ( R01 NS37237 ).
PY - 2012/5/15
Y1 - 2012/5/15
N2 - We studied activation magnitudes in core, belt, and parabelt auditory cortex in adults with normal hearing (NH) and unilateral hearing loss (UHL) using an interrupted, single-event design and monaural stimulation with random spectrographic sounds. NH patients had one ear blocked and received stimulation on the side matching the intact ear in UHL. The objective was to determine whether the side of deafness affected lateralization and magnitude of evoked blood oxygen level-dependent responses across different auditory cortical fields (ACFs). Regardless of ear of stimulation, NH showed larger contralateral responses in several ACFs. With right ear stimulation in UHL, ipsilateral responses were larger compared to NH in core and belt ACFs, indicating neuroplasticity in the right hemisphere. With left ear stimulation in UHL, only posterior core ACFs showed larger ipsilateral responses, suggesting that most ACFs in the left hemisphere had greater resilience against reduced crossed inputs from a deafferented right ear. Parabelt regions located posterolateral to core and belt auditory cortex showed reduced activation in UHL compared to NH irrespective of RE/LE stimulation and lateralization of inputs. Thus, the effect in UHL compared to NH differed by ACF and ear of deafness.
AB - We studied activation magnitudes in core, belt, and parabelt auditory cortex in adults with normal hearing (NH) and unilateral hearing loss (UHL) using an interrupted, single-event design and monaural stimulation with random spectrographic sounds. NH patients had one ear blocked and received stimulation on the side matching the intact ear in UHL. The objective was to determine whether the side of deafness affected lateralization and magnitude of evoked blood oxygen level-dependent responses across different auditory cortical fields (ACFs). Regardless of ear of stimulation, NH showed larger contralateral responses in several ACFs. With right ear stimulation in UHL, ipsilateral responses were larger compared to NH in core and belt ACFs, indicating neuroplasticity in the right hemisphere. With left ear stimulation in UHL, only posterior core ACFs showed larger ipsilateral responses, suggesting that most ACFs in the left hemisphere had greater resilience against reduced crossed inputs from a deafferented right ear. Parabelt regions located posterolateral to core and belt auditory cortex showed reduced activation in UHL compared to NH irrespective of RE/LE stimulation and lateralization of inputs. Thus, the effect in UHL compared to NH differed by ACF and ear of deafness.
KW - Adult unilateral deafness
KW - Auditory cortex
KW - Neuroplasticity
KW - Single-event BOLD response
UR - http://www.scopus.com/inward/record.url?scp=84860240312&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2012.02.066
DO - 10.1016/j.brainres.2012.02.066
M3 - Article
C2 - 22502976
AN - SCOPUS:84860240312
SN - 0006-8993
VL - 1454
SP - 33
EP - 47
JO - Brain Research
JF - Brain Research
ER -