Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat

J. M. Close, J. J. Neil, A. D. Loewy

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

When N-methyl-d,l-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.

Original languageEnglish
Pages (from-to)393-396
Number of pages4
JournalBrain Research
Volume249
Issue number2
DOIs
StatePublished - Oct 14 1982

Keywords

  • A5 catecholamine cell group
  • N-methyl aspartate
  • aminophosphonovalerate
  • excitotoxin antagonists

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