Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat

J. M. Close; J. J. Neil; A. D. Loewy

doi:10.1016/0006-8993(82)90076-2

Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat

J. M. Close, J. J. Neil, A. D. Loewy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

When N-methyl-d,l-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Brain Research
Volume	249
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(82)90076-2
State	Published - Oct 14 1982

Keywords

A5 catecholamine cell group
N-methyl aspartate
aminophosphonovalerate
excitotoxin antagonists

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10.1016/0006-8993(82)90076-2

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title = "Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat",

abstract = "When N-methyl-d,l-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.",

keywords = "A5 catecholamine cell group, N-methyl aspartate, aminophosphonovalerate, excitotoxin antagonists",

author = "Close, {J. M.} and Neil, {J. J.} and Loewy, {A. D.}",

note = "Funding Information: This work was supported by a grant-in-aid~ 80 723) from the American Heart Association wilh funds contributedin part by the Missouri Heart A,,. sociation and USPHS grants HL-25449 and GM-07220. A.D.L. is an EstablishedI nvestigatoor f Ihc American Heart Association.",

year = "1982",

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doi = "10.1016/0006-8993(82)90076-2",

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journal = "Brain Research",

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T1 - Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat

AU - Close, J. M.

AU - Neil, J. J.

AU - Loewy, A. D.

N1 - Funding Information: This work was supported by a grant-in-aid~ 80 723) from the American Heart Association wilh funds contributedin part by the Missouri Heart A,,. sociation and USPHS grants HL-25449 and GM-07220. A.D.L. is an EstablishedI nvestigatoor f Ihc American Heart Association.

PY - 1982/10/14

Y1 - 1982/10/14

N2 - When N-methyl-d,l-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.

AB - When N-methyl-d,l-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.

KW - A5 catecholamine cell group

KW - N-methyl aspartate

KW - aminophosphonovalerate

KW - excitotoxin antagonists

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AN - SCOPUS:0019991410

SN - 0006-8993

VL - 249

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EP - 396

JO - Brain Research

JF - Brain Research

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ER -

Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat

Abstract

Keywords

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