Actin dynamics: Assembly and disassembly of actin networks

Martin A. Wear, Dorothy A. Schafer, John A. Cooper

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP2 and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.

Original languageEnglish
Pages (from-to)R891-R895
JournalCurrent Biology
Issue number24
StatePublished - Dec 14 2000


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