TY - JOUR
T1 - Actin and endocytosis
T2 - mechanisms and phylogeny
AU - Galletta, Brian J.
AU - Cooper, John A.
N1 - Funding Information:
We acknowledge the support from the National Institutes of Health (GM38542 to JAC and GM077887 to BJG) for supporting our work described herein and preparation of this manuscript.
PY - 2009/2
Y1 - 2009/2
N2 - The regulated assembly of actin filament networks is a crucial part of endocytosis, with crucial temporal and spatial relationships between proteins of the endocytic and actin assembly machinery. Of particular importance has been a wealth of studies in budding and fission yeast. Cell biology approaches, combined with molecular genetics, have begun to uncover the complexity of the regulation of actin dynamics during the endocytic process. In a wide range of organisms, clathrin-mediated endocytosis appears to be linked to Arp2/3-mediated actin assembly. The conservation of the components, across a wide range eukaryotic species, suggests that the partnership between endocytosis and actin may be evolutionarily ancient.
AB - The regulated assembly of actin filament networks is a crucial part of endocytosis, with crucial temporal and spatial relationships between proteins of the endocytic and actin assembly machinery. Of particular importance has been a wealth of studies in budding and fission yeast. Cell biology approaches, combined with molecular genetics, have begun to uncover the complexity of the regulation of actin dynamics during the endocytic process. In a wide range of organisms, clathrin-mediated endocytosis appears to be linked to Arp2/3-mediated actin assembly. The conservation of the components, across a wide range eukaryotic species, suggests that the partnership between endocytosis and actin may be evolutionarily ancient.
UR - http://www.scopus.com/inward/record.url?scp=60749098725&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2009.01.006
DO - 10.1016/j.ceb.2009.01.006
M3 - Review article
C2 - 19186047
AN - SCOPUS:60749098725
SN - 0955-0674
VL - 21
SP - 20
EP - 27
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -