Actin and endocytosis: mechanisms and phylogeny

Brian J. Galletta, John A. Cooper

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations


The regulated assembly of actin filament networks is a crucial part of endocytosis, with crucial temporal and spatial relationships between proteins of the endocytic and actin assembly machinery. Of particular importance has been a wealth of studies in budding and fission yeast. Cell biology approaches, combined with molecular genetics, have begun to uncover the complexity of the regulation of actin dynamics during the endocytic process. In a wide range of organisms, clathrin-mediated endocytosis appears to be linked to Arp2/3-mediated actin assembly. The conservation of the components, across a wide range eukaryotic species, suggests that the partnership between endocytosis and actin may be evolutionarily ancient.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 2009


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