238 Scopus citations


In this study, Millman and colleagues report a differentiation strategy to generate β-like cells from human pluripotent stem cells with islet-like dynamic insulin release that rapidly reverses diabetes in mice. The authors elucidate that stage-specific control of TGF-β signaling during endocrine induction and maturation to be critical for robust function.

Original languageEnglish
Pages (from-to)351-365
Number of pages15
JournalStem Cell Reports
Issue number2
StatePublished - Feb 12 2019


  • cell therapy
  • diabetes
  • differentiation
  • glucose-stimulated insulin secretion
  • human embryonic stem cells
  • human induced pluripotent stem cells
  • islets
  • pancreas
  • transplantation
  • β cells


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