TY - JOUR
T1 - Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells
AU - Velazco-Cruz, Leonardo
AU - Song, Jiwon
AU - Maxwell, Kristina G.
AU - Goedegebuure, Madeleine M.
AU - Augsornworawat, Punn
AU - Hogrebe, Nathaniel J.
AU - Millman, Jeffrey R.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/2/12
Y1 - 2019/2/12
N2 - In this study, Millman and colleagues report a differentiation strategy to generate β-like cells from human pluripotent stem cells with islet-like dynamic insulin release that rapidly reverses diabetes in mice. The authors elucidate that stage-specific control of TGF-β signaling during endocrine induction and maturation to be critical for robust function.
AB - In this study, Millman and colleagues report a differentiation strategy to generate β-like cells from human pluripotent stem cells with islet-like dynamic insulin release that rapidly reverses diabetes in mice. The authors elucidate that stage-specific control of TGF-β signaling during endocrine induction and maturation to be critical for robust function.
KW - cell therapy
KW - diabetes
KW - differentiation
KW - glucose-stimulated insulin secretion
KW - human embryonic stem cells
KW - human induced pluripotent stem cells
KW - islets
KW - pancreas
KW - transplantation
KW - β cells
UR - http://www.scopus.com/inward/record.url?scp=85061052087&partnerID=8YFLogxK
U2 - 10.1016/j.stemcr.2018.12.012
DO - 10.1016/j.stemcr.2018.12.012
M3 - Article
C2 - 30661993
AN - SCOPUS:85061052087
SN - 2213-6711
VL - 12
SP - 351
EP - 365
JO - Stem Cell Reports
JF - Stem Cell Reports
IS - 2
ER -