Acoustic molecular imaging and targeted drug delivery with perfluorocarbon nanoparticles

Gregory M. Lanza, Michael S. Hughes, Jon N. Marsh, Michael J. Scott, Huiying Zhang, Elizabeth K. Lacy, John S. Allen, Samuel A. Wickline

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Advances in molecular biology and cellular biochemistry are providing new opportunities for diagnostic medical imaging to "see" beyond the anatomical manifestations of disease to the earliest biochemical signatures of disease. Liquid perfluorocarbon nanoparticles provide inherent acoustic contrast when bound to targets, e.g., fibrin deposits in a thrombus, but unbound nanoparticles are undetectable. This nanoparticle platform may be further functionalized with paramagnetic metals, such as gadolinium, or radionuclides, with homing ligands, like anti-α vβ 3-integrins, and therapeutic agents. Acoustic imaging of densely distributed biomarkers, e.g., fibrin epitopes, is readily accommodated with fundamental imaging, but for sparse biomarkers, e.g., integrins, we have developed and implemented novel, nonlinear imaging techniques based upon information-theoretic receivers (i.e., thermodynamic receivers). These novel receivers allow sensitive direct imaging of contrast development.

Original languageEnglish
Title of host publication4th International Symposium on Therapeutic Ultrasound
Pages120-123
Number of pages4
DOIs
StatePublished - Mar 28 2005
Event4th International Symposium on Therapeutic Ultrasound - Kyoto, Japan
Duration: Sep 18 2004Sep 20 2004

Publication series

NameAIP Conference Proceedings
Volume754
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium on Therapeutic Ultrasound
CountryJapan
CityKyoto
Period09/18/0409/20/04

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  • Cite this

    Lanza, G. M., Hughes, M. S., Marsh, J. N., Scott, M. J., Zhang, H., Lacy, E. K., Allen, J. S., & Wickline, S. A. (2005). Acoustic molecular imaging and targeted drug delivery with perfluorocarbon nanoparticles. In 4th International Symposium on Therapeutic Ultrasound (pp. 120-123). (AIP Conference Proceedings; Vol. 754). https://doi.org/10.1063/1.1901616