ACMSD: A Novel Target for Modulating NAD + Homeostasis

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalTrends in Endocrinology and Metabolism
Volume30
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • ACMSD
  • NAD
  • metabolism
  • niacin
  • tryptophan

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