ACMSD: A Novel Target for Modulating NAD                         +                          Homeostasis

Jun Yoshino

doi:10.1016/j.tem.2019.02.002

ACMSD: A Novel Target for Modulating NAD ⁺ Homeostasis

Jun Yoshino

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

NAD ⁺ has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD ⁺ metabolism and overexpression of human ACMSD leads to niacin dependency for NAD ⁺ biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD ⁺ deficiency.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	Trends in Endocrinology and Metabolism
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/j.tem.2019.02.002
State	Published - Apr 2019

Keywords

ACMSD
NAD
metabolism
niacin
tryptophan

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10.1016/j.tem.2019.02.002

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title = "ACMSD: A Novel Target for Modulating NAD + Homeostasis",

abstract = " NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency.",

keywords = "ACMSD, NAD, metabolism, niacin, tryptophan",

author = "Jun Yoshino",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = apr,

doi = "10.1016/j.tem.2019.02.002",

language = "English",

volume = "30",

pages = "229--232",

journal = "Trends in Endocrinology and Metabolism",

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T2 - A Novel Target for Modulating NAD + Homeostasis

AU - Yoshino, Jun

PY - 2019/4

Y1 - 2019/4

N2 - NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency.

AB - NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency.

KW - ACMSD

KW - NAD

KW - metabolism

KW - niacin

KW - tryptophan

UR - http://www.scopus.com/inward/record.url?scp=85061827195&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2019.02.002

DO - 10.1016/j.tem.2019.02.002

M3 - Short survey

C2 - 30799186

AN - SCOPUS:85061827195

SN - 1043-2760

VL - 30

SP - 229

EP - 232

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 4

ER -

ACMSD: A Novel Target for Modulating NAD ⁺ Homeostasis

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