ACMSD: A Novel Target for Modulating NAD + Homeostasis

Jun Yoshino

Research output: Contribution to journalShort surveypeer-review

15 Scopus citations


NAD + has a pivotal role in regulating many biological processes. A recent study (Palzer et al., Cell Rep. 2018, 25;1359–1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD + metabolism and overexpression of human ACMSD leads to niacin dependency for NAD + biosynthesis in mice, providing important insights into human diseases associated with niacin/NAD + deficiency.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalTrends in Endocrinology and Metabolism
Issue number4
StatePublished - Apr 2019


  • NAD
  • metabolism
  • niacin
  • tryptophan


Dive into the research topics of 'ACMSD: A Novel Target for Modulating NAD + Homeostasis'. Together they form a unique fingerprint.

Cite this