Acid-sensing ion channels in pain and disease

John A. Wemmie, Rebecca J. Taugher, Collin J. Kreple

Research output: Contribution to journalReview articlepeer-review

418 Scopus citations


Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level. Studies aimed at clarifying their physiological importance have suggested roles for ASICs in pain, neurological and psychiatric disease. This Review highlights recent findings linking these channels to physiology and disease. In addition, it discusses some of the implications for therapy and points out questions that remain unanswered.

Original languageEnglish
Pages (from-to)461-471
Number of pages11
JournalNature Reviews Neuroscience
Issue number7
StatePublished - Jul 2013


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