TY - JOUR
T1 - Accuracy of combined quantitative diffusion-weighted MRI and routine contrast-enhanced MRI in discrimination of benign and malignant salivary gland tumors
AU - Nada, Ayman
AU - Hady, Dina
AU - Youssef, Ayda
AU - Mahmoud, Esmat
AU - Assad, Ramy Edward
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: Preoperative imaging of salivary gland tumors is important for predicting and differentiating benign from malignant tumors, and for aiding management planning. We aimed to investigate the accuracy of combined quantitative diffusion-weighted magnetic resonance imaging (MRI) and routine contrast-enhanced MRI in the evaluation of salivary gland tumors and the differentiation of benign from malignant tumors. Results: This study included 51 patients with a total of 16 benign and 35 malignant lesions that were detected by histopathological analysis. There was a statistically significant difference between the apparent diffusion coefficient values (ADC) of malignant and benign lesions (0.69 ± 0.22 × 10−3 mm2/s and 1.39 ± 0.52 × 10−3 mm2/s respectively). The optimal cut-off ADC value was 1.08 with 75% specificity and 97% sensitivity. The routine contrast-enhanced MRI had predicted benign and malignant tumors with 65% sensitivity and 44% specificity. The sensitivity and specificity were greatly increased when quantitative diffusion-weighted MRI was combined with routine contrast-enhanced MRI: 100%, and 88% respectively. A receiver operating curve was generated. The area under curve was 0.88 (p < 0.001, 95% CI: 0.76–0.99). Conclusion: Combined quantitative diffusion-weighted MRI with ADC measurements and routine contrast-enhanced magnetic resonance imaging are helpful tools for the evaluation of salivary gland tumors and help differentiate benign from malignant lesions.
AB - Background: Preoperative imaging of salivary gland tumors is important for predicting and differentiating benign from malignant tumors, and for aiding management planning. We aimed to investigate the accuracy of combined quantitative diffusion-weighted magnetic resonance imaging (MRI) and routine contrast-enhanced MRI in the evaluation of salivary gland tumors and the differentiation of benign from malignant tumors. Results: This study included 51 patients with a total of 16 benign and 35 malignant lesions that were detected by histopathological analysis. There was a statistically significant difference between the apparent diffusion coefficient values (ADC) of malignant and benign lesions (0.69 ± 0.22 × 10−3 mm2/s and 1.39 ± 0.52 × 10−3 mm2/s respectively). The optimal cut-off ADC value was 1.08 with 75% specificity and 97% sensitivity. The routine contrast-enhanced MRI had predicted benign and malignant tumors with 65% sensitivity and 44% specificity. The sensitivity and specificity were greatly increased when quantitative diffusion-weighted MRI was combined with routine contrast-enhanced MRI: 100%, and 88% respectively. A receiver operating curve was generated. The area under curve was 0.88 (p < 0.001, 95% CI: 0.76–0.99). Conclusion: Combined quantitative diffusion-weighted MRI with ADC measurements and routine contrast-enhanced magnetic resonance imaging are helpful tools for the evaluation of salivary gland tumors and help differentiate benign from malignant lesions.
KW - apparent diffusion coefficient
KW - contrast-enhanced MRI
KW - Diffusion-weighted MRI
KW - salivary gland tumors
UR - http://www.scopus.com/inward/record.url?scp=85082940329&partnerID=8YFLogxK
U2 - 10.1177/1971400920913973
DO - 10.1177/1971400920913973
M3 - Article
C2 - 32223516
AN - SCOPUS:85082940329
SN - 1971-4009
VL - 33
SP - 216
EP - 223
JO - Neuroradiology Journal
JF - Neuroradiology Journal
IS - 3
ER -