Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy

Melissa Swiecki, Marco Colonna

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Plasmacytoid DC (pDC) secrete type I IFN in response to viruses and RNA/DNA/immunocomplexes. Type I IFN confer resistance to viral infections and promote innate and adaptive immune responses. pDC also produce cytokines and chemokines that influence recruitment and function of T cells and differentiation of B cells. Thus, pDC have been implicated both in protective immune responses and in induction of tolerance. In this Viewpoint, we discuss how the recruitment and accumulation of pDC may impact pathogenesis of several diseases and how pDC can be targeted for therapeutic interventions.

Original languageEnglish
Pages (from-to)2094-2098
Number of pages5
JournalEuropean Journal of Immunology
Volume40
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Autoimmunity
  • IFN
  • Plasmacytoid DC
  • Tolerance
  • Virus

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