TY - JOUR
T1 - Acceptability of in Utero Hematopoietic Cell Transplantation for Sickle Cell Disease
AU - Antiel, Ryan M.
AU - Halpern, Scott D.
AU - Stevens, Evelyn M.
AU - Vrecenak, Jesse D.
AU - Patterson, Chavis A.
AU - Tchume-Johnson, Trudy
AU - Smith-Whitley, Kim
AU - Peranteau, William H.
AU - Flake, Alan W.
AU - Barakat, Lamia P.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background. In utero hematopoietic cell transplantation (IUHCT) has curative potential for sickle cell disease (SCD) but carries a risk of fetal demise. Methods. We assessed the conditions under which parents of children with SCD and young adults with SCD would consider IUHCT in a future pregnancy, given a 5% fixed risk of fetal demise. Participants were randomized to consider a hypothetical cure rate (20%, 40%, or 70%). Subsequently, cure rate was either increased or decreased depending on the previous answer to reveal the lowest acceptable rate. Participants also completed the Pediatric Research Participation Questionnaire (PRPQ) and an omission scale. Results. Overall, 74 of 79 (94%) participants were willing to consider IUHCT, and 52 (66%) participants accepted IUHCT at a cure rate of 40%, the estimated rate of therapeutic mixed chimerism. Participants with higher scores on the PRPQ perceived benefits scale were more likely to participate at lower cure rates (OR 1.08, p=0.007) and participants with a greater degree of omission bias were less likely to participate at lower cure rates (OR 0.83, p=0.04). Demographics and SCD severity were not significantly associated with acceptability of IUHCT. Conclusion. This study suggests that the majority of parents >and young adults would consider IUHCT under expected therapeutic conditions.
AB - Background. In utero hematopoietic cell transplantation (IUHCT) has curative potential for sickle cell disease (SCD) but carries a risk of fetal demise. Methods. We assessed the conditions under which parents of children with SCD and young adults with SCD would consider IUHCT in a future pregnancy, given a 5% fixed risk of fetal demise. Participants were randomized to consider a hypothetical cure rate (20%, 40%, or 70%). Subsequently, cure rate was either increased or decreased depending on the previous answer to reveal the lowest acceptable rate. Participants also completed the Pediatric Research Participation Questionnaire (PRPQ) and an omission scale. Results. Overall, 74 of 79 (94%) participants were willing to consider IUHCT, and 52 (66%) participants accepted IUHCT at a cure rate of 40%, the estimated rate of therapeutic mixed chimerism. Participants with higher scores on the PRPQ perceived benefits scale were more likely to participate at lower cure rates (OR 1.08, p=0.007) and participants with a greater degree of omission bias were less likely to participate at lower cure rates (OR 0.83, p=0.04). Demographics and SCD severity were not significantly associated with acceptability of IUHCT. Conclusion. This study suggests that the majority of parents >and young adults would consider IUHCT under expected therapeutic conditions.
KW - decision making
KW - fetal therapy
KW - hematopoietic stem cell transplantation
KW - risk
KW - sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85030697754&partnerID=8YFLogxK
U2 - 10.1177/0272989X17707214
DO - 10.1177/0272989X17707214
M3 - Article
C2 - 28490230
AN - SCOPUS:85030697754
SN - 0272-989X
VL - 37
SP - 914
EP - 921
JO - Medical Decision Making
JF - Medical Decision Making
IS - 8
ER -