Acceptability of in Utero Hematopoietic Cell Transplantation for Sickle Cell Disease

Ryan M. Antiel, Scott D. Halpern, Evelyn M. Stevens, Jesse D. Vrecenak, Chavis A. Patterson, Trudy Tchume-Johnson, Kim Smith-Whitley, William H. Peranteau, Alan W. Flake, Lamia P. Barakat

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background. In utero hematopoietic cell transplantation (IUHCT) has curative potential for sickle cell disease (SCD) but carries a risk of fetal demise. Methods. We assessed the conditions under which parents of children with SCD and young adults with SCD would consider IUHCT in a future pregnancy, given a 5% fixed risk of fetal demise. Participants were randomized to consider a hypothetical cure rate (20%, 40%, or 70%). Subsequently, cure rate was either increased or decreased depending on the previous answer to reveal the lowest acceptable rate. Participants also completed the Pediatric Research Participation Questionnaire (PRPQ) and an omission scale. Results. Overall, 74 of 79 (94%) participants were willing to consider IUHCT, and 52 (66%) participants accepted IUHCT at a cure rate of 40%, the estimated rate of therapeutic mixed chimerism. Participants with higher scores on the PRPQ perceived benefits scale were more likely to participate at lower cure rates (OR 1.08, p=0.007) and participants with a greater degree of omission bias were less likely to participate at lower cure rates (OR 0.83, p=0.04). Demographics and SCD severity were not significantly associated with acceptability of IUHCT. Conclusion. This study suggests that the majority of parents >and young adults would consider IUHCT under expected therapeutic conditions.

Original languageEnglish
Pages (from-to)914-921
Number of pages8
JournalMedical Decision Making
Issue number8
StatePublished - Nov 1 2017


  • decision making
  • fetal therapy
  • hematopoietic stem cell transplantation
  • risk
  • sickle cell disease


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