TY - GEN
T1 - Accelerated arteriogenesis and vessel branching using dll4/vegf delivery system
AU - Niu, Hong
AU - Gao, Ning
AU - Dang, Yu
AU - Guan, Ya
AU - Guan, Jianjun
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Regeneration of arteries is of importance in treating some vascular diseases. However, how vessel branching affecting arteriogenesis remains incompletely understood. Different kinds of endothelial cells are involved in arteriogenesis, offering various functions in building the vascular networks. Tip endothelial cell that has filopodial structure is one of the most important cell types in vessel branching. Studies have demonstrated that vascular endothelial growth factor (VEGF) and delta-like 4 (Dll4) signaling pathways play important roles in regulating endothelial tip cell behavior for vessel branching. In this study, we have built a delivery system based on VEGF, Dll4, and a thermosensitive and reactive oxygen species (ROS) sensitive hydrogel. We hypothesized that the delivery system can promote the formation of vessels, extension of filopodia and rapid formation of arterioles.
AB - Statement of Purpose: Regeneration of arteries is of importance in treating some vascular diseases. However, how vessel branching affecting arteriogenesis remains incompletely understood. Different kinds of endothelial cells are involved in arteriogenesis, offering various functions in building the vascular networks. Tip endothelial cell that has filopodial structure is one of the most important cell types in vessel branching. Studies have demonstrated that vascular endothelial growth factor (VEGF) and delta-like 4 (Dll4) signaling pathways play important roles in regulating endothelial tip cell behavior for vessel branching. In this study, we have built a delivery system based on VEGF, Dll4, and a thermosensitive and reactive oxygen species (ROS) sensitive hydrogel. We hypothesized that the delivery system can promote the formation of vessels, extension of filopodia and rapid formation of arterioles.
UR - https://www.scopus.com/pages/publications/85065428578
M3 - Conference contribution
AN - SCOPUS:85065428578
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 526
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -