Absence of ototoxicity of teichomycin A2 in guinea pigs

R. E. Brummett; K. E. Fox; M. Warchol; D. Himes

doi:10.1128/AAC.31.4.612

Absence of ototoxicity of teichomycin A₂ in guinea pigs

R. E. Brummett
, K. E. Fox
, M. Warchol
, D. Himes

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Teichomycin A₂ is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A₂ was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A₂.

Original language	English
Pages (from-to)	612-613
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	31
Issue number	4
DOIs	https://doi.org/10.1128/AAC.31.4.612
State	Published - 1987

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title = "Absence of ototoxicity of teichomycin A2 in guinea pigs",

abstract = "Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.",

author = "Brummett, \{R. E.\} and Fox, \{K. E.\} and M. Warchol and D. Himes",

year = "1987",

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journal = "Antimicrobial agents and chemotherapy",

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T1 - Absence of ototoxicity of teichomycin A2 in guinea pigs

AU - Brummett, R. E.

AU - Fox, K. E.

AU - Warchol, M.

AU - Himes, D.

PY - 1987

Y1 - 1987

N2 - Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.

AB - Teichomycin A2 is a new antibiotic that is similar to vancomycin. Because vancomycin is reported to be ototoxic, teichomycin A2 was tested for ototoxicity. No evidence of ototoxicity was found. Furthermore, ethacrynic acid, a diuretic that augments the ototoxicity of many drugs, did not enhance ototoxicity with teichomycin A2.

UR - https://www.scopus.com/pages/publications/0023132970

U2 - 10.1128/AAC.31.4.612

DO - 10.1128/AAC.31.4.612

M3 - Article

C2 - 2955741

AN - SCOPUS:0023132970

SN - 0066-4804

VL - 31

SP - 612

EP - 613

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

Absence of ototoxicity of teichomycin A₂ in guinea pigs

Abstract

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