Abnormalities in cardiac structure and function in adults with sickle cell disease are not associated with pulmonary hypertension

Jessica E. Knight-Perry, Lisa De Las Fuentes, Alan D. Waggoner, Raymond G. Hoffmann, Morey A. Blinder, Victor G. Dávila-Román, Joshua J. Field

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: In sickle cell disease (SCD), pulmonary hypertension (assessed by tricuspid regurgitant jet [TRJ] velocity ≥ 2.5 m/sec) is associated with increased mortality. The relationships among TRJ velocity and left ventricular (LV) and right ventricular (RV) systolic and diastolic function (i.e., relaxation and compliance) have not been well characterized in SCD. Methods: A prospective study was conducted in 53 ambulatory adults with SCD (mean age, 34 years; range, 21-65 years) and 33 African American controls to define the relationship between LV and RV function and TRJ velocity using echocardiography. Results: Subjects with SCD had larger left and right atrial volumes and increased LV mass compared with controls. When patients with SCD were compared with controls, LV and RV relaxation (i.e., E′) were similar. Among subjects with SCD, pulmonary hypertension (TRJ ≥ 2.5 m/sec) was present in 40%. Higher TRJ velocity was correlated with larger left atrial volumes in patients with SCD. Additionally, some measures of LV (peak A, lateral and septal annular E/E′ ratio) and RV (tricuspid valve E/E′ ratio) compliance were correlated with TRJ velocity. No other measures of LV and RV systolic function or LV diastolic function (i.e., relaxation and compliance) were associated with TRJ velocity. Conclusions: Ambulatory adults with SCD exhibited structural (i.e., LV and RV chamber enlargement) and functional (i.e., higher surrogate measures of LV and RV filling pressure) abnormalities compared with the control group. In subjects with SCD, few abnormalities of LV and RV structure and function were associated with TRJ velocity.

Original languageEnglish
Pages (from-to)1285-1290
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume24
Issue number11
DOIs
StatePublished - Nov 1 2011

Keywords

  • Diastolic dysfunction
  • Pulmonary hypertension
  • Sickle cell disease

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