Abnormal Platelet Aggregation in Severe Combined Immunodeficiency Disease with Adenosine Deaminase Deficiency

A. L. Schwartz, S. H. Polmar, R. C. Stern, D. H. Cowan

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The platelets from a boy with adenosine deaminase deficiency‐severe combined immunodeficiency disease (ADA‐SCID) showed markedly subnormal aggregation in response to collagen and ADP. In contrast with normal platelets, ATP, AMP and adenosine had little effect in inhibiting ADP‐induced aggregation of ADA‐SCID platelets. These observations suggest that altered adenosine metabolism exists in ADA‐SCID platelets.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalBritish Journal of Haematology
Volume39
Issue number2
DOIs
StatePublished - Jun 1978

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