Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers

Imoh S. Okon, Ye Ding, Kathleen A. Coughlan, Qiongxin Wang, Ping Song, Doris M. Benbrook, Ming Hui Zou

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Neuropilin-1 (NRP-1) has emerged as an important driver of tumor-promoting phenotypes of human malignancies. However, incomplete knowledge exists as to how this single-pass transmembrane receptor mediates pleiotropic tumor-promoting functions. The purpose of this study was to evaluate NRP-1 expression and metastatic properties in 94 endometrial cancer and matching serum specimens and in a lung cancer cell line. We found that NRP-1 expression significantly correlated with increased tumoral expression of vascular endothelial growth factor 2 (VEGFR2) and serum levels of hepatocyte growth factor (HGF) and cell growth-stimulating factor (C-GSF). Tumoral NRP-1 also was positively associated with expression of NEDD9, a pro-metastatic protein. In the highly metastatic lung cancer cell line (H1792), stable LKB1 depletion caused increased migration in vitro and accentuated NRP-1 and NEDD9 expression in vivo. Our findings demonstrate that perturbed expression of these targets correlate with metastatic potential of endometrial and lung tumors, providing clinically-relevant biomarker applications for diagnostic and therapeutic targeting.

Original languageEnglish
Pages (from-to)7970-7978
Number of pages9
Issue number7
StatePublished - 2016


  • Endometrial and lung cancer
  • LKB1
  • NEDD9
  • NRP-1
  • Tumor metastases


Dive into the research topics of 'Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers'. Together they form a unique fingerprint.

Cite this