Aberrant expression of α-fetoprotein in intrahepatic cholangiocarcinoma: An exceptional occurrence

Kiran Vij, Hanlin L. Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A high level of serum α-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopathologic examination of surgically resected liver mass showed classic morphologic features of cholangiocarcinoma, with no hepatocellular carcinoma component identified. Immunohistochemically, the tumor cells were strongly and diffusely positive for AFP, CA19-9, and cytokeratin 19 and were negative for hepatocyte antigen. The patient's serum AFP level declined to 46.2 ng/mL 1 month after surgery. To the best of our knowledge, this is the first documented case of AFP-producing intrahepatic cholangiocarcinoma with immunohistochemical evidence confirming the tumor cells to be the source of high-level AFP production.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number2
StatePublished - Apr 2008


  • Cholangiocarcinoma
  • Liver
  • α-fetoprotein


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