TY - JOUR
T1 - A vision on the future of articular cartilage repair
AU - Cucchiarini, M.
AU - Madry, H.
AU - Guilak, F.
AU - Saris, D. B.
AU - Stoddart, M. J.
AU - Koon Wong, M.
AU - Roughley, P. J.
PY - 2014/5/6
Y1 - 2014/5/6
N2 - An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and regulatory organisations to debate the vision of cell therapy in articular cartilage repair and the measures that could be taken to narrow the gap between vision and current practice. Cell-based therapy is already in clinical use to enhance the repair of cartilage lesions, with procedures such as microfracture and articular chondrocyte implantation. However, even though long term follow up is good from a clinical perspective and some of the most rigorous randomised controlled trials in the regenerative medicine/orthopaedics field show beneficial effect, none of these options have proved successful in restoring the original articular cartilage structure and functionality in patients so far. With the remarkable recent advances in experimental research in cell biology (new sources for chondrocytes, stem cells), molecular biology (growth factors, genes), biomaterials, biomechanics, and translational science, a combined effort between scientists and clinicians with broad expertise may allow development of an improved cell therapy for cartilage repair. This position paper describes the current state of the art in the field to help define a procedure adapted to the clinical situation for upcoming translation in the patient.
AB - An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and regulatory organisations to debate the vision of cell therapy in articular cartilage repair and the measures that could be taken to narrow the gap between vision and current practice. Cell-based therapy is already in clinical use to enhance the repair of cartilage lesions, with procedures such as microfracture and articular chondrocyte implantation. However, even though long term follow up is good from a clinical perspective and some of the most rigorous randomised controlled trials in the regenerative medicine/orthopaedics field show beneficial effect, none of these options have proved successful in restoring the original articular cartilage structure and functionality in patients so far. With the remarkable recent advances in experimental research in cell biology (new sources for chondrocytes, stem cells), molecular biology (growth factors, genes), biomaterials, biomechanics, and translational science, a combined effort between scientists and clinicians with broad expertise may allow development of an improved cell therapy for cartilage repair. This position paper describes the current state of the art in the field to help define a procedure adapted to the clinical situation for upcoming translation in the patient.
KW - Articular cartilage repair
KW - Articular chondrocyte implantation
KW - Articular chondrocytes
KW - Cell and gene therapy
KW - Microfracture
KW - Neomaterials
KW - Progenitor cells
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84900497035&partnerID=8YFLogxK
U2 - 10.22203/eCM.v027sa03
DO - 10.22203/eCM.v027sa03
M3 - Article
C2 - 24802612
AN - SCOPUS:84900497035
SN - 1473-2262
VL - 27
SP - 12
EP - 16
JO - European Cells and Materials
JF - European Cells and Materials
IS - SUPPL
ER -