TY - JOUR
T1 - A Virus Is a Community
T2 - Diversity within Negative-Sense RNA Virus Populations
AU - González Aparicio, Lavinia J.
AU - López, Carolina B.
AU - Felt, Sébastien A.
N1 - Publisher Copyright:
Copyright © 2022 American Society for Microbiology. All Rights Reserved.
PY - 2022/9
Y1 - 2022/9
N2 - Negative-sense RNA virus populations are composed of diverse viral components that interact to form a community and shape the outcome of virus infections. At the genomic level, RNA virus populations consist not only of a homogeneous population of standard viral genomes but also of an extremely large number of genome variants, termed viral quasispecies, and nonstandard viral genomes, which include copy-back viral genomes, deletion viral genomes, mini viral RNAs, and hypermutated RNAs. At the particle level, RNA virus populations are composed of pleomorphic particles, particles missing or having additional genomes, and single particles or particle aggregates. As we continue discovering more about the components of negative-sense RNA virus populations and their crucial functions during virus infection, it will become more important to study RNA virus populations as a whole rather than their individual parts. In this review, we will discuss what is known about the components of negative-sense RNA virus communities, speculate how the components of the virus community interact, and summarize what vaccines and antiviral therapies are being currently developed to target or harness these components.
AB - Negative-sense RNA virus populations are composed of diverse viral components that interact to form a community and shape the outcome of virus infections. At the genomic level, RNA virus populations consist not only of a homogeneous population of standard viral genomes but also of an extremely large number of genome variants, termed viral quasispecies, and nonstandard viral genomes, which include copy-back viral genomes, deletion viral genomes, mini viral RNAs, and hypermutated RNAs. At the particle level, RNA virus populations are composed of pleomorphic particles, particles missing or having additional genomes, and single particles or particle aggregates. As we continue discovering more about the components of negative-sense RNA virus populations and their crucial functions during virus infection, it will become more important to study RNA virus populations as a whole rather than their individual parts. In this review, we will discuss what is known about the components of negative-sense RNA virus communities, speculate how the components of the virus community interact, and summarize what vaccines and antiviral therapies are being currently developed to target or harness these components.
KW - antiviral immunity
KW - copy-back viral genomes
KW - copy-backs
KW - deletion viral genomes
KW - filamentous particles
KW - multiple genome packaging
KW - negative-sense RNA virus
KW - nonstandard viral genomes
KW - semi-infectious particles
KW - viral quasispecies
KW - virion aggregation
KW - virus
KW - virus community
UR - http://www.scopus.com/inward/record.url?scp=85138460138&partnerID=8YFLogxK
U2 - 10.1128/mmbr.00086-21
DO - 10.1128/mmbr.00086-21
M3 - Review article
C2 - 35658541
AN - SCOPUS:85138460138
SN - 1092-2172
VL - 86
JO - Microbiology and Molecular Biology Reviews
JF - Microbiology and Molecular Biology Reviews
IS - 3
ER -