A view of human haematopoietic development from the Petri dish

Andrea Ditadi; Christopher M. Sturgeon; Gordon Keller

doi:10.1038/nrm.2016.127

A view of human haematopoietic development from the Petri dish

Andrea Ditadi
, Christopher M. Sturgeon
, Gordon Keller

Division of Hematology

Research output: Contribution to journal › Review article › peer-review

112 Scopus citations

Abstract

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

Original language	English
Pages (from-to)	56-67
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1038/nrm.2016.127
State	Published - Dec 19 2016

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10.1038/nrm.2016.127

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N2 - Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

AB - Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

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A view of human haematopoietic development from the Petri dish

Abstract

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