TY - JOUR
T1 - A view of human haematopoietic development from the Petri dish
AU - Ditadi, Andrea
AU - Sturgeon, Christopher M.
AU - Keller, Gordon
N1 - Publisher Copyright:
© 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2016/12/19
Y1 - 2016/12/19
N2 - Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.
AB - Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.
UR - http://www.scopus.com/inward/record.url?scp=84997050487&partnerID=8YFLogxK
U2 - 10.1038/nrm.2016.127
DO - 10.1038/nrm.2016.127
M3 - Review article
C2 - 27876786
AN - SCOPUS:84997050487
SN - 1471-0072
VL - 18
SP - 56
EP - 67
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 1
ER -