A view of human haematopoietic development from the Petri dish

Andrea Ditadi, Christopher M. Sturgeon, Gordon Keller

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

Original languageEnglish
Pages (from-to)56-67
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume18
Issue number1
DOIs
StatePublished - Dec 19 2016

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