A unique cardiac cytosolic acyltransferase with preferential selectivity for fatty acids that form cyclooxygenase/lipoxygenase metabolites and reverse essential fatty acid deficiency

Philip Needleman, Angela Wyche, Howard Sprecher, William J. Elliott, Alex Evers

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The rabbit heart contains a cytosolic enzyme which selectively incorporates polyunsaturated fatty acids into phosphatidylcholine. This unique acyltransferase is selective for fatty acids, thus far tested, that are substrates for cyclooxygenase or lipoxygenase (i.e., arachidonic, eicosapentaenoic, linoleic and dihomo-γ-linoleic acids) or which reverse the symptoms of essential fatty acid deficiency (columbinic acid). On the other hand, palmitic, oleic, 5,8,11-eicosatrienoic (n - 9, Mead acid), and docosatetraenoic acid (n - 6, adrenic acid) were not incorporated in phospholipids by the cytosolic acyltransferase. No such fatty acid selectivity was exhibited by the cytosolic acyl-CoA synthetase or by the acyltransferase activities present in cardiac microsomes and mitochondria.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume836
Issue number2
DOIs
StatePublished - Sep 11 1985

Keywords

  • (Rabbit heart)
  • Acyl transferase
  • Acyl-CoA synthetase
  • Fatty acid
  • Phospholipid

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