@article{6d7df412a2a14e40b11ec635bc36e4d9,
title = "A two-parameter model for three types of nuclepore filtration of leukocytes",
abstract = "Micropore filtration of leukocytes is one of the main methods for evaluating leukocytes' deformability. Here a biofluid mechanical model was proposed for three cases: (i) filtration under gravity; (ii) constant pressure filtration; (iii) constant flow rate filtration. In previous models, constant blood cell resistance was assumed. In this paper, when evaluating the filler resistance to leukocytes, not only the effect of the change in the driving pressure but also the difference in the deformability of individual leukocytes are taken into consideration. Moreover, based on Moessmer's experimental results, a probability distribution function for the transit time of polymorphonuclear cells (PMNs) through the filter is assumed. Finally, numerical curves are obtained for the above three types of filtration and the comparison between the theoretical and experimental results of PMNs for case (i) turns out to be satisfactory The two parameters in the model, A and B represent leukocytes' deformability under low and high pressures respectively.",
keywords = "Hemorheology, Leukocytes, Nuclepore filtration, Theoretical model",
author = "Shao Jinyu and {Van Zongyi}, Zongyi and Zhuang Fengyuan and {Sun Ruijuan}, Ruijuan",
note = "Funding Information: When blood cells pass through the filter membrane or the capillaries, they. present similar characteristics\[*.-'l so the technique of the nuclepore filtration of cell suspensions has been extensively applied to the study of blood cell rheotogy~ The rheological properties of leukocytes play an important role in microcirculation, blood flow arid other biological processes. Therefore, leukocyte rhe01ogy is receiving more and more concern in the field of bioengineering, and it is important to study the rheological behavior of leukocytes in vitro and in vivo. The deformability of leukocytes is a significant aspect in leukocyte rhdology. Nuctepore filtration experiments of teukocytes is one of the main methods for evaluating leukocytes' deformability. This experiment's major process is: let the dilute leukocyte suspension flow through the nuclepore filter membrane and measure the flow rate or the changes in the * Project supported by the National Natural Science Foundation of China i Department of Biorheology , Research Institute. China-Japan Friendship Hospital. Beijing 100029, P. R. China 2 Department of Mechanics.",
year = "1997",
doi = "10.1007/BF02453368",
language = "English",
volume = "18",
pages = "251--258",
journal = "Applied Mathematics and Mechanics (English Edition)",
issn = "0253-4827",
number = "3",
}