A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

M. C. Walker, R. G. Kurumbail, J. R. Kiefer, K. T. Moreland, C. M. Koboldt, P. C. Isakson, K. Seibert, J. K. Gierse

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Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology

Chemistry