A theory of cognitive control, aging cognition, and neuromodulation

Todd S. Braver; Deanna M. Barch

doi:10.1016/S0149-7634(02)00067-2

A theory of cognitive control, aging cognition, and neuromodulation

Todd S. Braver, Deanna M. Barch

Research output: Contribution to journal › Article › peer-review

499 Scopus citations

Abstract

A theory is described which links cognitive changes observed in normal aging to an underlying decline in the function of the dopamine (DA) system projection to prefrontal cortex (PFC). The theory postulates that this neural mechanism is integral to the representation, maintenance and updating of context information, and as such impacts cognitive control across a wide range of cognitive domains, including working memory, attention, and inhibition. Behavioral and brain imaging data in support of the theory are discussed, which demonstrate selective impairments in context processing among healthy older adults associated with abnormal PFC activation. These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined.

Original language	English
Pages (from-to)	809-817
Number of pages	9
Journal	Neuroscience and Biobehavioral Reviews
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/S0149-7634(02)00067-2
State	Published - Nov 2002

Keywords

Aging
Brain imaging
Computational model
Dopamine
Executive control
Functional magnetic resonance imaging
Prefrontal cortex
Working memory

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10.1016/S0149-7634(02)00067-2

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title = "A theory of cognitive control, aging cognition, and neuromodulation",

abstract = "A theory is described which links cognitive changes observed in normal aging to an underlying decline in the function of the dopamine (DA) system projection to prefrontal cortex (PFC). The theory postulates that this neural mechanism is integral to the representation, maintenance and updating of context information, and as such impacts cognitive control across a wide range of cognitive domains, including working memory, attention, and inhibition. Behavioral and brain imaging data in support of the theory are discussed, which demonstrate selective impairments in context processing among healthy older adults associated with abnormal PFC activation. These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined.",

keywords = "Aging, Brain imaging, Computational model, Dopamine, Executive control, Functional magnetic resonance imaging, Prefrontal cortex, Working memory",

author = "Braver, {Todd S.} and Barch, {Deanna M.}",

note = "Funding Information: This research was supported by NIA AG18138. The authors thank Martha Storandt for guidance and support in conducting behavioral studies, and Beth Keys, Carrie Racine and Ajay Satpute for assistance in data collection and analysis.",

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AU - Barch, Deanna M.

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AB - A theory is described which links cognitive changes observed in normal aging to an underlying decline in the function of the dopamine (DA) system projection to prefrontal cortex (PFC). The theory postulates that this neural mechanism is integral to the representation, maintenance and updating of context information, and as such impacts cognitive control across a wide range of cognitive domains, including working memory, attention, and inhibition. Behavioral and brain imaging data in support of the theory are discussed, which demonstrate selective impairments in context processing among healthy older adults associated with abnormal PFC activation. These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined.

KW - Aging

KW - Brain imaging

KW - Computational model

KW - Dopamine

KW - Executive control

KW - Functional magnetic resonance imaging

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KW - Working memory

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A theory of cognitive control, aging cognition, and neuromodulation

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