A tale of two switches: Redox regulation of adenosine-5′-phosphosulfate kinase in humans and plants

Jeremy S. Morris, Joseph M. Jez

Research output: Contribution to journalComment/debate

Abstract

The sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS) is a near-universal component of sulfur metabolism. In a report by Zhang et al. in this issue of Structure, X-ray crystal structures of the APS kinase domains from human PAPS synthase reveal dynamic substrate recognition and a regulatory “redox switch” analogous to that previously described only in plant APS kinases.

Original languageEnglish
Pages (from-to)757-759
Number of pages3
JournalStructure
Volume31
Issue number7
DOIs
StatePublished - Jul 6 2023

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