TY - JOUR
T1 - A tale of two pili
T2 - Assembly and function of pili in bacteria
AU - Kline, Kimberly A.
AU - Dodson, Karen W.
AU - Caparon, Michael G.
AU - Hultgren, Scott J.
N1 - Funding Information:
We thank Ashley Nenninger, Stefan Fälker and Fabrice Neiers for critical reading of this manuscript and helpful discussion. This work was supported by National Institutes of Health and Office of Research on Women's Health Specialized Center of Research DK64540, DK51406, AI48689, AI29549 and AI49950 (to S.J.H.); NIH grant AI38273 (M.G.C); and an AHA Postdoctoral Fellowship 0625736Z (K.A.K.).
PY - 2010/5
Y1 - 2010/5
N2 - Bacterial pili have long been recognized as mediators of initial host-pathogen interactions important for the progression of Gram-negative bacterial diseases. An appreciation of the role of pili on virulence in Gram-positive bacteria and the unique properties of their biogenesis is a rapidly emerging area of research. In this review, we focus on recent advances in one of the longest-studied Gram-negative pilus systems, the chaperone/usher assembled pili, along with the newcomer to the field, the sortase-assembled pili of Gram-positive bacteria. In both systems, a wealth of new structural and molecular details has emerged recently. In light of this, we explore similarities between chaperone/usher and sortase-assembled pilus biogenesis and highlight paradigms unique to each, with the goal of using knowledge of each system to raise new questions and inform future studies of the other.
AB - Bacterial pili have long been recognized as mediators of initial host-pathogen interactions important for the progression of Gram-negative bacterial diseases. An appreciation of the role of pili on virulence in Gram-positive bacteria and the unique properties of their biogenesis is a rapidly emerging area of research. In this review, we focus on recent advances in one of the longest-studied Gram-negative pilus systems, the chaperone/usher assembled pili, along with the newcomer to the field, the sortase-assembled pili of Gram-positive bacteria. In both systems, a wealth of new structural and molecular details has emerged recently. In light of this, we explore similarities between chaperone/usher and sortase-assembled pilus biogenesis and highlight paradigms unique to each, with the goal of using knowledge of each system to raise new questions and inform future studies of the other.
UR - http://www.scopus.com/inward/record.url?scp=77952549113&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2010.03.002
DO - 10.1016/j.tim.2010.03.002
M3 - Review article
C2 - 20378353
AN - SCOPUS:77952549113
VL - 18
SP - 224
EP - 232
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 5
ER -