A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant

David Ulaeto; Paul E. Lacy; David M. Kipnis; Osami Kanagawa; Emil R. Unanue

doi:10.1073/pnas.89.9.3927

A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant

David Ulaeto, Paul E. Lacy, David M. Kipnis, Osami Kanagawa, Emil R. Unanue

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Three experimental manipulations showed the suppressive effect of injection of complete Freund's adjuvant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i) Diabetes was inhibited in young NOD mice injected with the adjuvant, (ii) Recurrence of diabetes in mice transplanted with pancreatic islets was also inhibited when the recipients were injected with CFA. (iii) Injection of spleen lymphocytes from diabetic mice into male NOD mice transferred the diabetic state, but this transfer was markedly suppressed when the recipients were treated with CFA. In all three cases the spleen cells from the normoglycemic mice treated with CFA induced diabetes when transferred into NOD male mice. CFA, therefore, induces a state of T-cell dormancy, in which the islets are no longer subject to an immune attack.

Original language	English
Pages (from-to)	3927-3931
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	9
DOIs	https://doi.org/10.1073/pnas.89.9.3927
State	Published - 1992

Keywords

Adjuvants
Autoimmunity
Insulin-dependent diabetes mellitus

Access to Document

10.1073/pnas.89.9.3927

Cite this

@article{75cdd1a58f5f4f79bc3c1d85ae379823,

title = "A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant",

abstract = "Three experimental manipulations showed the suppressive effect of injection of complete Freund's adjuvant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i) Diabetes was inhibited in young NOD mice injected with the adjuvant, (ii) Recurrence of diabetes in mice transplanted with pancreatic islets was also inhibited when the recipients were injected with CFA. (iii) Injection of spleen lymphocytes from diabetic mice into male NOD mice transferred the diabetic state, but this transfer was markedly suppressed when the recipients were treated with CFA. In all three cases the spleen cells from the normoglycemic mice treated with CFA induced diabetes when transferred into NOD male mice. CFA, therefore, induces a state of T-cell dormancy, in which the islets are no longer subject to an immune attack.",

keywords = "Adjuvants, Autoimmunity, Insulin-dependent diabetes mellitus",

author = "David Ulaeto and Lacy, {Paul E.} and Kipnis, {David M.} and Osami Kanagawa and Unanue, {Emil R.}",

year = "1992",

doi = "10.1073/pnas.89.9.3927",

language = "English",

volume = "89",

pages = "3927--3931",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "9",

}

TY - JOUR

T1 - A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant

AU - Ulaeto, David

AU - Lacy, Paul E.

AU - Kipnis, David M.

AU - Kanagawa, Osami

AU - Unanue, Emil R.

PY - 1992

Y1 - 1992

N2 - Three experimental manipulations showed the suppressive effect of injection of complete Freund's adjuvant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i) Diabetes was inhibited in young NOD mice injected with the adjuvant, (ii) Recurrence of diabetes in mice transplanted with pancreatic islets was also inhibited when the recipients were injected with CFA. (iii) Injection of spleen lymphocytes from diabetic mice into male NOD mice transferred the diabetic state, but this transfer was markedly suppressed when the recipients were treated with CFA. In all three cases the spleen cells from the normoglycemic mice treated with CFA induced diabetes when transferred into NOD male mice. CFA, therefore, induces a state of T-cell dormancy, in which the islets are no longer subject to an immune attack.

AB - Three experimental manipulations showed the suppressive effect of injection of complete Freund's adjuvant (CFA) in the diabetic state of nonobese diabetic (NOD) mice. (i) Diabetes was inhibited in young NOD mice injected with the adjuvant, (ii) Recurrence of diabetes in mice transplanted with pancreatic islets was also inhibited when the recipients were injected with CFA. (iii) Injection of spleen lymphocytes from diabetic mice into male NOD mice transferred the diabetic state, but this transfer was markedly suppressed when the recipients were treated with CFA. In all three cases the spleen cells from the normoglycemic mice treated with CFA induced diabetes when transferred into NOD male mice. CFA, therefore, induces a state of T-cell dormancy, in which the islets are no longer subject to an immune attack.

KW - Adjuvants

KW - Autoimmunity

KW - Insulin-dependent diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=0026559333&partnerID=8YFLogxK

U2 - 10.1073/pnas.89.9.3927

DO - 10.1073/pnas.89.9.3927

M3 - Article

C2 - 1570315

AN - SCOPUS:0026559333

SN - 0027-8424

VL - 89

SP - 3927

EP - 3931

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 9

ER -

A T-cell dormant state in the autoimmune process of nonobese diabetic mice treated with complete Freund's adjuvant

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this