A systematic review of patient-reported outcome measures patients with chronic limb-threatening ischemia

Philip Goodney, Samir Shah, Yiyuan David Hu, Bjoern Suckow, Scott Kinlay, David G. Armstrong, Patrick Geraghty, Megan Patterson, Matthew Menard, Manesh R. Patel, Michael S. Conte

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Chronic limb-threatening ischemia (CLTI) causes significant morbidity with profound negative effects on health-related quality of life. As the prevalence of peripheral artery disease and diabetes continue to rise in our aging population, the public health impact of CLTI has escalated. Patient-reported outcome measures (PROMs) have become common and important measures for clinical evaluation in both clinical care and research. PROMs are important for the measurement of clinical effectiveness and cost effectiveness and for shared decision-making on treatment options. However, the PROMs used to describe the experience of patients with CLTI are heterogeneous, incomplete, and lack specific applicability to the underlying disease processes and diverse populations. For example, certain PROMs exist for patients with extremity wounds, and other PROMs exist for patients with pain, and still others exist for patients with vascular disease. Despite this multiplicity of tools, no single PROM encompasses all of the components necessary to describe the experiences of patients with CLTI. This significant unmet need is evident from both published reports and contemporary large-scale clinical trials in the field. In this systematic review, we review the current use of PROMs for patients with CLTI in clinical practice and in research trials and highlight the gaps that need to be addressed to develop a unifying PROM instrument for CLTI.

Original languageEnglish
Pages (from-to)1762-1775
Number of pages14
JournalJournal of Vascular Surgery
Issue number5
StatePublished - May 2022


  • Amputation
  • Chronic limb-threatening ischemia
  • Critical limb ischemia
  • Decision aid
  • Decision tool
  • Patient reported outcome
  • Peripheral artery disease
  • Shared decision-making
  • Surgical decision
  • Surgical decision-making


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