A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies

Ingrid Eshun-Wilson; Muhammad S. Jamil; T. Charles Witzel; David V. Glidded; Cheryl Johnson; Noelle Le Trouneau; Nathan Ford; Kathleen McGee; Chris Kemp; Stefan Baral; Sheree Schwartz; Elvin H. Geng

doi:10.1093/cid/ciab029

A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies

Ingrid Eshun-Wilson, Muhammad S. Jamil, T. Charles Witzel, David V. Glidded, Cheryl Johnson, Noelle Le Trouneau, Nathan Ford, Kathleen McGee, Chris Kemp, Stefan Baral, Sheree Schwartz, Elvin H. Geng

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Background: We conducted a systematic review and network meta-analysis to identify which human immunodeficiency virus (HIV) self-testing (HIVST) distribution strategies are most effective. Methods: We abstracted data from randomized controlled trials and observational studies published between 4 June 2006 and 4 June 2019. Results: We included 33 studies, yielding 6 HIVST distribution strategies. All distribution strategies increased testing uptake compared to standard testing: in sub-Saharan Africa, partner HIVST distribution ranked highest (78% probability); in North America, Asia, and the Pacific regions, web-based distribution ranked highest (93% probability), and facility based distribution ranked second in all settings. Across HIVST distribution strategies HIV positivity and linkage was similar to standard testing. Conclusions: A range of HIVST distribution strategies are effective in increasing HIV testing. HIVST distribution by sexual partners, web-based distribution, as well as health facility distribution strategies should be considered for implementation to expand the reach of HIV testing services.

Original language	English
Pages (from-to)	E1018-E1028
Journal	Clinical Infectious Diseases
Volume	73
Issue number	4
DOIs	https://doi.org/10.1093/cid/ciab029
State	Published - Aug 15 2021

Keywords

HIV self-testing
implementation
network meta-analysis
systematic review

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10.1093/cid/ciab029

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Eshun-Wilson, I., Jamil, M. S., Witzel, T. C., Glidded, D. V., Johnson, C., Le Trouneau, N., Ford, N., McGee, K., Kemp, C., Baral, S., Schwartz, S., & Geng, E. H. (2021). A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies. Clinical Infectious Diseases, 73(4), E1018-E1028. https://doi.org/10.1093/cid/ciab029

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title = "A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies",

abstract = "Background: We conducted a systematic review and network meta-analysis to identify which human immunodeficiency virus (HIV) self-testing (HIVST) distribution strategies are most effective. Methods: We abstracted data from randomized controlled trials and observational studies published between 4 June 2006 and 4 June 2019. Results: We included 33 studies, yielding 6 HIVST distribution strategies. All distribution strategies increased testing uptake compared to standard testing: in sub-Saharan Africa, partner HIVST distribution ranked highest (78% probability); in North America, Asia, and the Pacific regions, web-based distribution ranked highest (93% probability), and facility based distribution ranked second in all settings. Across HIVST distribution strategies HIV positivity and linkage was similar to standard testing. Conclusions: A range of HIVST distribution strategies are effective in increasing HIV testing. HIVST distribution by sexual partners, web-based distribution, as well as health facility distribution strategies should be considered for implementation to expand the reach of HIV testing services.",

keywords = "HIV self-testing, implementation, network meta-analysis, systematic review",

author = "Ingrid Eshun-Wilson and Jamil, {Muhammad S.} and Witzel, {T. Charles} and Glidded, {David V.} and Cheryl Johnson and {Le Trouneau}, Noelle and Nathan Ford and Kathleen McGee and Chris Kemp and Stefan Baral and Sheree Schwartz and Geng, {Elvin H.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2021",

month = aug,

day = "15",

doi = "10.1093/cid/ciab029",

language = "English",

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Eshun-Wilson, I, Jamil, MS, Witzel, TC, Glidded, DV, Johnson, C, Le Trouneau, N, Ford, N, McGee, K, Kemp, C, Baral, S, Schwartz, S & Geng, EH 2021, 'A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies', Clinical Infectious Diseases, vol. 73, no. 4, pp. E1018-E1028. https://doi.org/10.1093/cid/ciab029

A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies. / Eshun-Wilson, Ingrid; Jamil, Muhammad S.; Witzel, T. Charles et al.
In: Clinical Infectious Diseases, Vol. 73, No. 4, 15.08.2021, p. E1018-E1028.

Research output: Contribution to journal › Review article › peer-review

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T1 - A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies

AU - Eshun-Wilson, Ingrid

AU - Jamil, Muhammad S.

AU - Witzel, T. Charles

AU - Glidded, David V.

AU - Johnson, Cheryl

AU - Le Trouneau, Noelle

AU - Ford, Nathan

AU - McGee, Kathleen

AU - Kemp, Chris

AU - Baral, Stefan

AU - Schwartz, Sheree

AU - Geng, Elvin H.

PY - 2021/8/15

Y1 - 2021/8/15

N2 - Background: We conducted a systematic review and network meta-analysis to identify which human immunodeficiency virus (HIV) self-testing (HIVST) distribution strategies are most effective. Methods: We abstracted data from randomized controlled trials and observational studies published between 4 June 2006 and 4 June 2019. Results: We included 33 studies, yielding 6 HIVST distribution strategies. All distribution strategies increased testing uptake compared to standard testing: in sub-Saharan Africa, partner HIVST distribution ranked highest (78% probability); in North America, Asia, and the Pacific regions, web-based distribution ranked highest (93% probability), and facility based distribution ranked second in all settings. Across HIVST distribution strategies HIV positivity and linkage was similar to standard testing. Conclusions: A range of HIVST distribution strategies are effective in increasing HIV testing. HIVST distribution by sexual partners, web-based distribution, as well as health facility distribution strategies should be considered for implementation to expand the reach of HIV testing services.

AB - Background: We conducted a systematic review and network meta-analysis to identify which human immunodeficiency virus (HIV) self-testing (HIVST) distribution strategies are most effective. Methods: We abstracted data from randomized controlled trials and observational studies published between 4 June 2006 and 4 June 2019. Results: We included 33 studies, yielding 6 HIVST distribution strategies. All distribution strategies increased testing uptake compared to standard testing: in sub-Saharan Africa, partner HIVST distribution ranked highest (78% probability); in North America, Asia, and the Pacific regions, web-based distribution ranked highest (93% probability), and facility based distribution ranked second in all settings. Across HIVST distribution strategies HIV positivity and linkage was similar to standard testing. Conclusions: A range of HIVST distribution strategies are effective in increasing HIV testing. HIVST distribution by sexual partners, web-based distribution, as well as health facility distribution strategies should be considered for implementation to expand the reach of HIV testing services.

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AN - SCOPUS:85109006045

SN - 1058-4838

VL - 73

SP - E1018-E1028

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 4

ER -

A Systematic Review and Network Meta-analyses to Assess the Effectiveness of Human Immunodeficiency Virus (HIV) Self-testing Distribution Strategies

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