A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer

Andrea J. Dwyer; Caitlin C. Murphy; C. Richard Boland; R. Garcia; Heather Hampel; Paul Limburg; Jan Lowery; A. G. Zauber; Stephen Waring; Sharyn Worrall; Jose Perea; Rebecca Siegel; Jeffrey Lee; Christine Molmenti; Cynthia L. Sears; Phillip Buckhaults; Richard Hayes; Hisham Hussan; Noel de Miranda; Claire Palles; Luis Diaz; Mingyang Song; Andrea Cercek; Christopher H. Lieu; Swati G. Patel; Jordan J. Karlitz; Yin Cao; Josh Demb; Patrick Blatchford; B. Risendal; Elsa Weltzien; Anil Wali; Phil Daschner; H. Loomans-Kropp; R. Flores; Caleb L. Levell; K. Wehling; Jessica Martin; Curt Pesmen; Violet Kuchar; Ryan Soisson; A. Davis; Dennis Ahnen

doi:10.1053/j.gastro.2019.04.049

A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer

Andrea J. Dwyer, Caitlin C. Murphy, C. Richard Boland, R. Garcia, Heather Hampel, Paul Limburg, Jan Lowery, A. G. Zauber, Stephen Waring, Sharyn Worrall, Jose Perea, Rebecca Siegel, Jeffrey Lee, Christine Molmenti, Cynthia L. Sears, Phillip Buckhaults, Richard Hayes, Hisham Hussan, Noel de Miranda, Claire PallesLuis Diaz, Mingyang Song, Andrea Cercek, Christopher H. Lieu, Swati G. Patel, Jordan J. Karlitz, Yin Cao, Josh Demb, Patrick Blatchford, B. Risendal, Elsa Weltzien, Anil Wali, Phil Daschner, H. Loomans-Kropp, R. Flores, Caleb L. Levell, K. Wehling, Jessica Martin, Curt Pesmen, Violet Kuchar, Ryan Soisson, A. Davis, Dennis Ahnen

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Original language	English
Pages (from-to)	280-288
Number of pages	9
Journal	Gastroenterology
Volume	157
Issue number	2
DOIs	https://doi.org/10.1053/j.gastro.2019.04.049
State	Published - Aug 2019

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Dwyer, A. J., Murphy, C. C., Boland, C. R., Garcia, R., Hampel, H., Limburg, P., Lowery, J., Zauber, A. G., Waring, S., Worrall, S., Perea, J., Siegel, R., Lee, J., Molmenti, C., Sears, C. L., Buckhaults, P., Hayes, R., Hussan, H., de Miranda, N., ... Ahnen, D. (2019). A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer. Gastroenterology, 157(2), 280-288. https://doi.org/10.1053/j.gastro.2019.04.049

@article{9c51a4e62f8d485e9a5c0bf62c2810a6,

title = "A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer",

author = "Dwyer, {Andrea J.} and Murphy, {Caitlin C.} and Boland, {C. Richard} and R. Garcia and Heather Hampel and Paul Limburg and Jan Lowery and Zauber, {A. G.} and Stephen Waring and Sharyn Worrall and Jose Perea and Rebecca Siegel and Jeffrey Lee and Christine Molmenti and Sears, {Cynthia L.} and Phillip Buckhaults and Richard Hayes and Hisham Hussan and {de Miranda}, Noel and Claire Palles and Luis Diaz and Mingyang Song and Andrea Cercek and Lieu, {Christopher H.} and Patel, {Swati G.} and Karlitz, {Jordan J.} and Yin Cao and Josh Demb and Patrick Blatchford and B. Risendal and Elsa Weltzien and Anil Wali and Phil Daschner and H. Loomans-Kropp and R. Flores and Levell, {Caleb L.} and K. Wehling and Jessica Martin and Curt Pesmen and Violet Kuchar and Ryan Soisson and A. Davis and Dennis Ahnen",

note = "Funding Information: Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting. Conflicts of interest The authors have made the following disclosures: C. Richard Boland has presented several lectures for Ambry Genetics. Heather Hampel is on the scientific advisory board for InVitae Genetics and Genome Medical and has stock in Genome Medical. She has performed collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc. Paul Limburg serves as co-Chief Medical Officer for Exact Sciences through a contracted services agreement with Mayo Clinic. Dr Limburg and Mayo Clinic have contractual rights to receive royalties through this agreement. Cynthia L. Sears received ongoing research support from Bristol Meyers Squibb and has delivered a Merck Lecture on Microbiome and CRC. Phillip Buckhaults reports receiving a commercial research grant from Janssen Research and Development. Luis Diaz is a member of the board of directors of Personal Genome Diagnostics (PGDx) and Jounce Therapeutics. He holds equity in PapGene, PGDx and Neophore. He is a paid consultant for PGDx and Neophore. He is an uncompensated consultant for Merck but has received research support for trials from Merck. He is an inventor of multiple licensed patents related to technology for circulating tumor DNA analyses and mismatch repair deficiency for diagnosis and therapy (WO2016077553A1) from Johns Hopkins University. Some of these licenses and relationships are associated with equity or royalty payments to Luis Diaz. The terms of all these arrangements are being managed by Johns Hopkins and Memorial Sloan Kettering in accordance with their conflict of interest policies. In addition, in the past 5 years, Luis Diaz has participated as a paid consultant for Merck and for one-time engagements with Caris, Lyndra, Genocea Biosciences, Illumina, and Cell Design Labs. Jordan J. Karlitz is an Advisor, Exact Sciences, and a consultant and on the speaker's bureau of Myriad Genetics. Dennis Ahnen is on the speakers bureau for Ambrose genetics and is a scientific advisor for Cancer Prevention Pharmaceuticals. Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting. The authors thank the following individuals for their assistance in guiding the meeting planning: Scott Kopetz, MD, Matthew Young, MD, Paul Schroy, MD, Andrew Chan, MD, Richard Goldberg, MD, Robert Smith, PhD, Ian Tomlinson, PhD, Kathy Helzouer, MD, Doug Corley, MD, and Patrick Mahoney. Conflicts of interest The authors have made the following disclosures: C. Richard Boland has presented several lectures for Ambry Genetics. Heather Hampel is on the scientific advisory board for InVitae Genetics and Genome Medical and has stock in Genome Medical. She has performed collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc. Paul Limburg serves as co-Chief Medical Officer for Exact Sciences through a contracted services agreement with Mayo Clinic. Dr Limburg and Mayo Clinic have contractual rights to receive royalties through this agreement. Cynthia L. Sears received ongoing research support from Bristol Meyers Squibb and has delivered a Merck Lecture on Microbiome and CRC. Phillip Buckhaults reports receiving a commercial research grant from Janssen Research and Development. Luis Diaz is a member of the board of directors of Personal Genome Diagnostics (PGDx) and Jounce Therapeutics. He holds equity in PapGene, PGDx and Neophore. He is a paid consultant for PGDx and Neophore. He is an uncompensated consultant for Merck but has received research support for trials from Merck. He is an inventor of multiple licensed patents related to technology for circulating tumor DNA analyses and mismatch repair deficiency for diagnosis and therapy (WO2016077553A1) from Johns Hopkins University. Some of these licenses and relationships are associated with equity or royalty payments to Luis Diaz. The terms of all these arrangements are being managed by Johns Hopkins and Memorial Sloan Kettering in accordance with their conflict of interest policies. In addition, in the past 5 years, Luis Diaz has participated as a paid consultant for Merck and for one-time engagements with Caris, Lyndra, Genocea Biosciences, Illumina, and Cell Design Labs. Jordan J. Karlitz is an Advisor, Exact Sciences, and a consultant and on the speaker's bureau of Myriad Genetics. Dennis Ahnen is on the speakers bureau for Ambrose genetics and is a scientific advisor for Cancer Prevention Pharmaceuticals. Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting.",

year = "2019",

month = aug,

doi = "10.1053/j.gastro.2019.04.049",

language = "English",

volume = "157",

pages = "280--288",

journal = "Gastroenterology",

issn = "0016-5085",

number = "2",

}

Dwyer, AJ, Murphy, CC, Boland, CR, Garcia, R, Hampel, H, Limburg, P, Lowery, J, Zauber, AG, Waring, S, Worrall, S, Perea, J, Siegel, R, Lee, J, Molmenti, C, Sears, CL, Buckhaults, P, Hayes, R, Hussan, H, de Miranda, N, Palles, C, Diaz, L, Song, M, Cercek, A, Lieu, CH, Patel, SG, Karlitz, JJ, Cao, Y, Demb, J, Blatchford, P, Risendal, B, Weltzien, E, Wali, A, Daschner, P, Loomans-Kropp, H, Flores, R, Levell, CL, Wehling, K, Martin, J, Pesmen, C, Kuchar, V, Soisson, R, Davis, A & Ahnen, D 2019, 'A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer', Gastroenterology, vol. 157, no. 2, pp. 280-288. https://doi.org/10.1053/j.gastro.2019.04.049

TY - JOUR

T1 - A Summary of the Fight Colorectal Cancer Working Meeting

T2 - Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer

AU - Dwyer, Andrea J.

AU - Murphy, Caitlin C.

AU - Boland, C. Richard

AU - Garcia, R.

AU - Hampel, Heather

AU - Limburg, Paul

AU - Lowery, Jan

AU - Zauber, A. G.

AU - Waring, Stephen

AU - Worrall, Sharyn

AU - Perea, Jose

AU - Siegel, Rebecca

AU - Lee, Jeffrey

AU - Molmenti, Christine

AU - Sears, Cynthia L.

AU - Buckhaults, Phillip

AU - Hayes, Richard

AU - Hussan, Hisham

AU - de Miranda, Noel

AU - Palles, Claire

AU - Diaz, Luis

AU - Song, Mingyang

AU - Cercek, Andrea

AU - Lieu, Christopher H.

AU - Patel, Swati G.

AU - Karlitz, Jordan J.

AU - Cao, Yin

AU - Demb, Josh

AU - Blatchford, Patrick

AU - Risendal, B.

AU - Weltzien, Elsa

AU - Wali, Anil

AU - Daschner, Phil

AU - Loomans-Kropp, H.

AU - Flores, R.

AU - Levell, Caleb L.

AU - Wehling, K.

AU - Martin, Jessica

AU - Pesmen, Curt

AU - Kuchar, Violet

AU - Soisson, Ryan

AU - Davis, A.

AU - Ahnen, Dennis

N1 - Funding Information: Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting. Conflicts of interest The authors have made the following disclosures: C. Richard Boland has presented several lectures for Ambry Genetics. Heather Hampel is on the scientific advisory board for InVitae Genetics and Genome Medical and has stock in Genome Medical. She has performed collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc. Paul Limburg serves as co-Chief Medical Officer for Exact Sciences through a contracted services agreement with Mayo Clinic. Dr Limburg and Mayo Clinic have contractual rights to receive royalties through this agreement. Cynthia L. Sears received ongoing research support from Bristol Meyers Squibb and has delivered a Merck Lecture on Microbiome and CRC. Phillip Buckhaults reports receiving a commercial research grant from Janssen Research and Development. Luis Diaz is a member of the board of directors of Personal Genome Diagnostics (PGDx) and Jounce Therapeutics. He holds equity in PapGene, PGDx and Neophore. He is a paid consultant for PGDx and Neophore. He is an uncompensated consultant for Merck but has received research support for trials from Merck. He is an inventor of multiple licensed patents related to technology for circulating tumor DNA analyses and mismatch repair deficiency for diagnosis and therapy (WO2016077553A1) from Johns Hopkins University. Some of these licenses and relationships are associated with equity or royalty payments to Luis Diaz. The terms of all these arrangements are being managed by Johns Hopkins and Memorial Sloan Kettering in accordance with their conflict of interest policies. In addition, in the past 5 years, Luis Diaz has participated as a paid consultant for Merck and for one-time engagements with Caris, Lyndra, Genocea Biosciences, Illumina, and Cell Design Labs. Jordan J. Karlitz is an Advisor, Exact Sciences, and a consultant and on the speaker's bureau of Myriad Genetics. Dennis Ahnen is on the speakers bureau for Ambrose genetics and is a scientific advisor for Cancer Prevention Pharmaceuticals. Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting. The authors thank the following individuals for their assistance in guiding the meeting planning: Scott Kopetz, MD, Matthew Young, MD, Paul Schroy, MD, Andrew Chan, MD, Richard Goldberg, MD, Robert Smith, PhD, Ian Tomlinson, PhD, Kathy Helzouer, MD, Doug Corley, MD, and Patrick Mahoney. Conflicts of interest The authors have made the following disclosures: C. Richard Boland has presented several lectures for Ambry Genetics. Heather Hampel is on the scientific advisory board for InVitae Genetics and Genome Medical and has stock in Genome Medical. She has performed collaborative research with Ambry Genetics, InVitae Genetics, and Myriad Genetic Laboratories, Inc. Paul Limburg serves as co-Chief Medical Officer for Exact Sciences through a contracted services agreement with Mayo Clinic. Dr Limburg and Mayo Clinic have contractual rights to receive royalties through this agreement. Cynthia L. Sears received ongoing research support from Bristol Meyers Squibb and has delivered a Merck Lecture on Microbiome and CRC. Phillip Buckhaults reports receiving a commercial research grant from Janssen Research and Development. Luis Diaz is a member of the board of directors of Personal Genome Diagnostics (PGDx) and Jounce Therapeutics. He holds equity in PapGene, PGDx and Neophore. He is a paid consultant for PGDx and Neophore. He is an uncompensated consultant for Merck but has received research support for trials from Merck. He is an inventor of multiple licensed patents related to technology for circulating tumor DNA analyses and mismatch repair deficiency for diagnosis and therapy (WO2016077553A1) from Johns Hopkins University. Some of these licenses and relationships are associated with equity or royalty payments to Luis Diaz. The terms of all these arrangements are being managed by Johns Hopkins and Memorial Sloan Kettering in accordance with their conflict of interest policies. In addition, in the past 5 years, Luis Diaz has participated as a paid consultant for Merck and for one-time engagements with Caris, Lyndra, Genocea Biosciences, Illumina, and Cell Design Labs. Jordan J. Karlitz is an Advisor, Exact Sciences, and a consultant and on the speaker's bureau of Myriad Genetics. Dennis Ahnen is on the speakers bureau for Ambrose genetics and is a scientific advisor for Cancer Prevention Pharmaceuticals. Funding Funding for this meeting was provided directly from Fight CRC unrestricted grants and private donations. No industry partners provided financial incentives to support this meeting.

PY - 2019/8

Y1 - 2019/8

UR - http://www.scopus.com/inward/record.url?scp=85069604861&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2019.04.049

DO - 10.1053/j.gastro.2019.04.049

M3 - Article

C2 - 31095950

AN - SCOPUS:85069604861

SN - 0016-5085

VL - 157

SP - 280

EP - 288

JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer

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