A suite of neurophotonic tools to underpin the contribution of internal brain states in fMRI

Philipp Mächler, Thomas Broggini, Celine Mateo, Martin Thunemann, Natalie Fomin-Thunemann, Patrick R. Doran, Ikbal Sencan, Kivilcim Kilic, Michèle Desjardins, Hana Uhlirova, Mohammad A. Yaseen, David A. Boas, Andreas A. Linninger, Massimo Vergassola, Xin Yu, Laura D. Lewis, Jonathan R. Polimeni, Bruce R. Rosen, Sava Sakadžić, Richard B. BuxtonMartin Lauritzen, David Kleinfeld, Anna Devor

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Recent developments in optical microscopy, applicable for large-scale and longitudinal imaging of cortical activity in behaving animals, open unprecedented opportunities to gain a deeper understanding of neurovascular and neurometabolic coupling during different brain states. Future studies will leverage these tools to deliver foundational knowledge about brain state-dependent regulation of cerebral blood flow and metabolism, as well as regulation as a function of brain maturation and aging. This knowledge is of critical importance to interpret hemodynamic signals observed with functional magnetic resonance imaging (fMRI).

Original languageEnglish
Article number100273
JournalCurrent Opinion in Biomedical Engineering
Volume18
DOIs
StatePublished - Jun 2021

Keywords

  • CMRO
  • Glycolysis
  • Hemodynamic
  • Neuromodulation
  • Optical imaging

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