A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela; Amit A. Patel; Mai Chan Lau; Chi Ching Goh; Rasha Msallam; Wan Ting Kong; Michael Fehlings; Sandra Hubert; Josephine Lum; Yannick Simoni; Benoit Malleret; Francesca Zolezzi; Jinmiao Chen; Michael Poidinger; Ansuman T. Satpathy; Carlos Briseno; Christian Wohn; Bernard Malissen; Kenneth M. Murphy; Alexander A. Maini; Leen Vanhoutte; Martin Guilliams; Emmanuel Vial; Laurent Hennequin; Evan Newell; Lai Guan Ng; Philippe Musette; Simon Yona; Feriel Hacini-Rachinel; Florent Ginhoux

doi:10.1016/j.immuni.2019.03.001

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela
, Amit A. Patel
, Mai Chan Lau
, Chi Ching Goh
, Rasha Msallam
, Wan Ting Kong
, Michael Fehlings
, Sandra Hubert
, Josephine Lum
, Yannick Simoni
, Benoit Malleret
, Francesca Zolezzi
, Jinmiao Chen
, Michael Poidinger
, Ansuman T. Satpathy
, Carlos Briseno
, Christian Wohn
, Bernard Malissen
, Kenneth M. Murphy
, Alexander A. Maini

Leen Vanhoutte, Martin Guilliams, Emmanuel Vial, Laurent Hennequin, Evan Newell, Lai Guan Ng, Philippe Musette, Simon Yona, Feriel Hacini-Rachinel, Florent Ginhoux

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

Original language	English
Pages (from-to)	1069-1083.e8
Journal	Immunity
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.03.001
State	Published - Apr 16 2019

Keywords

VEGF
VEGFR
XCR1
activation
cDC1
dendritic cell
langerin
monocyte
neutrophil
recruitment

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10.1016/j.immuni.2019.03.001

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Janela, B., Patel, A. A., Lau, M. C., Goh, C. C., Msallam, R., Kong, W. T., Fehlings, M., Hubert, S., Lum, J., Simoni, Y., Malleret, B., Zolezzi, F., Chen, J., Poidinger, M., Satpathy, A. T., Briseno, C., Wohn, C., Malissen, B., Murphy, K. M., ... Ginhoux, F. (2019). A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils. Immunity, 50(4), 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

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title = "A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils",

abstract = "Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.",

keywords = "VEGF, VEGFR, XCR1, activation, cDC1, dendritic cell, langerin, monocyte, neutrophil, recruitment",

author = "Baptiste Janela and Patel, \{Amit A.\} and Lau, \{Mai Chan\} and Goh, \{Chi Ching\} and Rasha Msallam and Kong, \{Wan Ting\} and Michael Fehlings and Sandra Hubert and Josephine Lum and Yannick Simoni and Benoit Malleret and Francesca Zolezzi and Jinmiao Chen and Michael Poidinger and Satpathy, \{Ansuman T.\} and Carlos Briseno and Christian Wohn and Bernard Malissen and Murphy, \{Kenneth M.\} and Maini, \{Alexander A.\} and Leen Vanhoutte and Martin Guilliams and Emmanuel Vial and Laurent Hennequin and Evan Newell and Ng, \{Lai Guan\} and Philippe Musette and Simon Yona and Feriel Hacini-Rachinel and Florent Ginhoux",

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year = "2019",

month = apr,

day = "16",

doi = "10.1016/j.immuni.2019.03.001",

language = "English",

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Janela, B, Patel, AA, Lau, MC, Goh, CC, Msallam, R, Kong, WT, Fehlings, M, Hubert, S, Lum, J, Simoni, Y, Malleret, B, Zolezzi, F, Chen, J, Poidinger, M, Satpathy, AT, Briseno, C, Wohn, C, Malissen, B, Murphy, KM, Maini, AA, Vanhoutte, L, Guilliams, M, Vial, E, Hennequin, L, Newell, E, Ng, LG, Musette, P, Yona, S, Hacini-Rachinel, F & Ginhoux, F 2019, 'A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils', Immunity, vol. 50, no. 4, pp. 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

TY - JOUR

T1 - A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

AU - Janela, Baptiste

AU - Patel, Amit A.

AU - Lau, Mai Chan

AU - Goh, Chi Ching

AU - Msallam, Rasha

AU - Kong, Wan Ting

AU - Fehlings, Michael

AU - Hubert, Sandra

AU - Lum, Josephine

AU - Simoni, Yannick

AU - Malleret, Benoit

AU - Zolezzi, Francesca

AU - Chen, Jinmiao

AU - Poidinger, Michael

AU - Satpathy, Ansuman T.

AU - Briseno, Carlos

AU - Wohn, Christian

AU - Malissen, Bernard

AU - Murphy, Kenneth M.

AU - Maini, Alexander A.

AU - Vanhoutte, Leen

AU - Guilliams, Martin

AU - Vial, Emmanuel

AU - Hennequin, Laurent

AU - Newell, Evan

AU - Ng, Lai Guan

AU - Musette, Philippe

AU - Yona, Simon

AU - Hacini-Rachinel, Feriel

AU - Ginhoux, Florent

PY - 2019/4/16

Y1 - 2019/4/16

N2 - Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

AB - Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

KW - VEGF

KW - VEGFR

KW - XCR1

KW - activation

KW - cDC1

KW - dendritic cell

KW - langerin

KW - monocyte

KW - neutrophil

KW - recruitment

UR - https://www.scopus.com/pages/publications/85063330533

U2 - 10.1016/j.immuni.2019.03.001

DO - 10.1016/j.immuni.2019.03.001

M3 - Article

C2 - 30926233

AN - SCOPUS:85063330533

SN - 1074-7613

VL - 50

SP - 1069-1083.e8

JO - Immunity

JF - Immunity

IS - 4

ER -

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Abstract

Keywords

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