@article{ac658534fd3249d28e9162b2fa93bf61,
title = "A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils",
abstract = "Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.",
keywords = "VEGF, VEGFR, XCR1, activation, cDC1, dendritic cell, langerin, monocyte, neutrophil, recruitment",
author = "Baptiste Janela and Patel, {Amit A.} and Lau, {Mai Chan} and Goh, {Chi Ching} and Rasha Msallam and Kong, {Wan Ting} and Michael Fehlings and Sandra Hubert and Josephine Lum and Yannick Simoni and Benoit Malleret and Francesca Zolezzi and Jinmiao Chen and Michael Poidinger and Satpathy, {Ansuman T.} and Carlos Briseno and Christian Wohn and Bernard Malissen and Murphy, {Kenneth M.} and Maini, {Alexander A.} and Leen Vanhoutte and Martin Guilliams and Emmanuel Vial and Laurent Hennequin and Evan Newell and Ng, {Lai Guan} and Philippe Musette and Simon Yona and Feriel Hacini-Rachinel and Florent Ginhoux",
note = "Funding Information: This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestl{\'e} Skin Health R&D/GALDERMA. We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex (ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL) and PHENOMIN. We thank the SIgN Immunomonitoring platform, supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. Y.S. B.M. F.Z. J.C. M.P. A.T.S. C.B. C.W. B.M. K.M.M. A.A.M. L.V. M.G. E.V. L.H. E.N. L.G.N. P.M. S.Y. F.H.-R. and F.G. participated in the planning, design, and interpretation of experiments and results. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. and A.T.S. carried out experiments and/or analyzed data. B.J. and F.G. wrote the manuscript. B.J. F.G. E.V. and F.H.-R. have one patent related to this work: International Publication Number WO 2018/224614 Al. Funding Information: This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestl{\'e} Skin Health R&D/GALDERMA . We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex ( ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL ) and PHENOMIN . We thank the SIgN Immunomonitoring platform , supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011 . Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = apr,
day = "16",
doi = "10.1016/j.immuni.2019.03.001",
language = "English",
volume = "50",
pages = "1069--1083.e8",
journal = "Immunity",
issn = "1074-7613",
number = "4",
}