A study of neurotrophism in a primate model

Susan E. Mackinnon, A. Lee Dellon, Goran Lundborg, A. R. Hudson, Daniel A. Hunter

Research output: Contribution to journalArticle

110 Scopus citations


This study investigated the existence of neurotrophism in a primate model. In eight adult cynomolgus monkeys the sensory component of the femoral nerve was sectioned and introduced into the proximal channel of a silicone Y chamber. The proximal stump was given distal choices of various tissues inserted into the remaining arms of the silicone Y chamber. The targets presented were combinations of tendon, muscle, intact distal nerve, distal nerve graft, or an empty silicone channel. After 6 weeks, ultrastructural analysis confirmed axonal growth toward distal nerve tissue, while minimal or no nerve regeneration was directed toward tendon, muscle, or the empty silicone channel. The results showed that either a distal nerve stump or a nerve graft will act as a specific target to the regenerating primate proximal nerve stump.

Original languageEnglish
Pages (from-to)888-894
Number of pages7
JournalJournal of Hand Surgery
Issue number6
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint Dive into the research topics of 'A study of neurotrophism in a primate model'. Together they form a unique fingerprint.

  • Cite this

    Mackinnon, S. E., Dellon, A. L., Lundborg, G., Hudson, A. R., & Hunter, D. A. (1986). A study of neurotrophism in a primate model. Journal of Hand Surgery, 11(6), 888-894. https://doi.org/10.1016/S0363-5023(86)80244-1